Background: Cephaelis ipecacuanha is a medicinal plant used in folk medicine for the treatment of amebiasis. However, the pharmacological properties of this species remain poorly understood. Objective: Characterize chemical composition and in vitro antiprotozoal activity of Cephaelis ipecacuanha. Method: The aqueous extract was lyophilized using the Chisrt Alpha apparatus and transferred to 96-well plates at concentrations ranging from 62.5 to 1000 μg / mL. The antiprotozoal activities against Trypanosoma cruzi, Leishmania brasiliensis, and L. infantum were evaluated after 72h incubation. Fibroblasts incubated at the same conditions for 24h were used as a cytotoxicity control. The readings were performed by spectrophotometry after staining with resazurin. The chemical composition of the extract was analyzed by High-Performance Liquid Chromatography (HPLC-DAD). Results: The results demonstrated that C. ipecacuanha had moderate antiprotozoal activity against T. cruzi. However, its cytotoxicity against the fibroblasts was significantly higher. Conclusion: This finding suggests that the use of this plant by the population, besides not having significant benefits, can cause associated health risks.
Os estudos que buscam identificar o perfil e as expectativas dos estudantes de Odontologia, fornecem informações importantes para melhorar a formação acadêmica nessa área da saúde. Este trabalho tem como objetivo investigar por meio de uma revisão integrativa da literatura, o perfil e as expectativas profissionais dos estudantes de Odontologia em diferentes regiões do país. Através de uma abordagem exploratória descritiva, foi realizado uma revisão bibliográfica abrangente. Resultando na formação de um perfil predominante, onde as universidades apresentam em maioria estudantes do sexo feminino, com idade média entre 18 e 30 anos e pertencentes a famílias de classe média a alta. Além disso, foi identificado um desejo generalizado entre os entrevistados de realizarem uma pós-graduação, bem como a intenção de conciliar o trabalho no setor público com a prática privada. Quanto às expectativas salariais, a média mencionada pelos estudantes foi de 5 a 8 salários-mínimos.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
334 Leonard St
Brooklyn, NY 11211
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.