Myofibroblastic tumor (MIT) is characterized by the infiltration of different organs, most commonly the lungs, with nodular lesions composed of myofibroblasts and inflammatory cells, which can be identified by specific patterns in the immunohistochemical studies. When it involves the peritoneum it is difficult to eradicate, tends to relapse and it has an invasive behavior, requiring its differentiation from peritoneal carcinomatosis. Treatment may be surgical excision, the use of non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids. We report a 30 years old female with an unremarkable medical history, presenting with abdominal pain and progressive abdominal distention. A CT scan revealed multiple peritoneal nodular lesions. A surgical biopsy was reported as a myofibroblast and inflammatory cell infiltrate. Immunohistochemical staining was consistent with MIT. Given the extensive involvement of the peritoneum surgical therapy was not considered appropriate and treatment with NSAID and glucocorticoids was started. No response was observed after 6 months, therefore infliximab therapy was started. After 10 months of follow-up the patient is well, returned to normal life, ascites improved and resolved and CT scan showed partial regression or stabilization of the lesions.
Introduction 3. Materials 3.1 Materials 3.2 Cell Culture 3.3 Analysis of cell number, size and intracellular amino acids 3.4 SDS-PAGE and immunoblotting 3.5 Measurement of System A uptake 3.6 Proteomic analysis of TAP-tagged SNAT2 complexes 3.7 Statistical analysis 4. Results 4.1 MCF-7 cells express SNAT1, SNAT2 and exhibit functional System A transport 4.2 Effects of sustained System A inhibition on cell growth and proliferation 4.3 Chronic cell incubation with Me-AIB and intracellular amino acid levels 4.4 System A-induced modulation of mTOR signalling 4.5 Analysis of TAP-tagged SNAT2 protein complexes 5. Discussion 6. Acknowledgment 7. References Abbreviations: Methyl aminoisobutyrate, Me-AIB; mTORC, mammalian target of rapamycin complex; TAP, tandem affinity purification; MLCK, myosin light chain kinase; BCAA, branched chain amino acids.
En este artículo se analizan y comparan las estrategias de Vinculación con el Medio (VcM) de dos universidades del sur de Chile: Inacap sede Coyhaique y Universidad del Bío Bío. El acercamiento al objeto de estudio se realiza desde el enfoque de la Nueva Teoría Estratégica (NTE) de la Comunicación, que revela aprendizajes significativos y que contribuye a optimizar tanto las áreas de VcM como de comunicaciones al interior de las Instituciones de Educación Superior (IES) bajo estudio. Preliminarmente hay un trabajo que profundiza y aclara aspectos que, a la luz de la Nueva Teoría Estratégica de la Comunicación, se aplican al estudio comparativo, para finalizar con los principales hallazgos y conclusiones.
435 hemophiliacs are usually being attended in the La Paz hemophilia Center (Madrid, Spain). 257 (59%) of these patients have been infected by the human immunodeficiency virus (HIV-1) because of human plasma derivate substitution therapy. The infection has been more frequent among the severely affected patients and among the most treated patients. 82% of the infected patients are between 14 and 40 years old. By December 1991, 95 (37%) of 257 seropositive patients have developed full-blown AIDS. The most frequent opportunistic infection they had suffered was esophageal can-didiasis. Looking for an evolution marker, we can point that the patients older than 35 years with CD4 levels below 200/mm3 had the worst prognosis. There was no difference in the evolution among the patients aged below 17 and those aged between 17 and 35 years. The amount of concentrate used between 1980 and 1984 did not hold any relation to the evolution. 49 patients (51%) of the 95 suffering from AIDS had died by December 1991. The evolution to the death was unrelated to the patient age, CD4 lymphocyte levels, and amount of substitution therapy. In our opinion, the most valuable marker could be the kind of opportunistic infection or tumor the patient suffers from. Finally, Retrovir has demonstrated to be useful in increasing the survival rate of the patients, but after 36 months of treatment, only 33% of those AIDS patients who began taking it remained alive. Retrovir was also used in asymptomatic patients, and during an average period of time of 15 months, a lesser bone marrow toxicity and a stabilization in CD4 lymphocyte levels could be observed, but this was unable to modify the disease progression in those patients who presented circulating p24 antigen.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.