Concerning the genetic factors of obesity, no consistent association between
populations has been reported, which may be due to the frequency of polymorphisms,
the lifestyle of studied populations and its interaction with other factors. We
studied a possible association of polymorphisms FTO rs9939609,
PPARG rs1801282, and ADIPOQ rs4632532 and
rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides,
cholesterol, HDL and LDL were measured. In addition, weight, height, waist
circumference and triceps skin thickness were recorded. High-energy diets and
sedentary behavior were evaluated with a validated questionnaire. In contrast with
other reports, only FTO rs9939609 was associated with obesity
related-traits, including BMI (p = 0.03), waist circumference
(p = 0.02), triceps skinfold (p = 0.03) and
waist/height ratio (p = 0.01), and also with cholesterol levels
(p = 0.02) and LDL (p = 0.009). Lower levels of
triglycerides (p=0.04) were related with presence of PPARG
rs1801282, while ADIPOQ rs4632532 showed an effect on HDL
(p = 0.03) levels. On the other hand, diet, physical activity and
screen time were not related with obesity. In summary, only FTO
rs9939609 was associated with obesity related-traits, while PPARG2
rs1801282 and ADIPOQ rs4632532 were involved in lipid
metabolism.
Objetivo. Buscar toda la información y evidencia disponible sobre el SARS-CoV-2 -que surgió en estos primeros 4 meses de 2020- y el embarazo. Metodología. Revisión sistemática en las bases de datos PubMed y Google Scholar, hasta el 25 de abril de 2020. Se buscó artículos publicados relacionados con mujeres embarazadas infectadas con SARS-CoV-2. No hubo restricción de idioma. La búsqueda se extendió a las referencias de los artículos encontrados. Resultados. La enfermedad COVID-19 en mujeres embarazadas se caracteriza porque más del 90% de las pacientes evoluciona en forma leve, 2% requiere ingresar a las unidades de cuidados intensivos. Una muerte materna ha sido reportada. La prematuridad es alrededor de 25%, con predominio de recién nacidos prematuros tardíos; aproximadamente el 9% se complica con rotura prematura de membranas; la mortalidad perinatal es baja o similar a la de la población general y no se ha demostrado la transmisión vertical. Conclusiones. Los ginecólogos obstetras deben prepararse para atender cada vez más casos con COVID-19 y, por lo tanto, es necesario tener su conocimiento. La enfermedad evoluciona de la misma manera que en las no embarazadas, genera mayor prematuridad, no se ha demostrado la transmisión vertical, pero hay altas posibilidades de transmisión horizontal durante el parto vaginal.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.