Pregnancies recovered from <scp>SARS‐CoV</scp>‐2 infection in second or third trimester: obstetric evolution

Gracia, Paulino Vigil-De; Caballero, Luis Carlos; Sánchez, J.; Espinosa, Jorge; Campana, Sara; Quintero, Arelys; Luo, Carlos; Ng, Jsc S. C.

doi:10.1002/uog.23134

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…18,19 The SARS-CoV-2 has been thought to cause inflammatory syndrome in the placenta, resulting in preterm birth, PROM, fetal distress, and stillbirth. 20 Upon entry into the human body, SARS-CoV-2 spike binds to ACE2 receptor through its receptorbinding domain. In a study examining ACE2 RNA in placental tissues obtained from all three trimesters, the ACE2 expression in the term placental tissues was not as high as in the first and second trimester placentas.…”

Section: Discussionmentioning

confidence: 99%

“…39 The SARS-CoV-2 has been proposed to induce inflammatory syndrome in human placenta, thereby, leading to preterm birth and PROM. 20 In the literature, the rate of preterm birth varies between 15.2 and 27.6%. 27,40 In a study, Kayem et al 41 reported that 27.6% of the patients had preterm birth, while 11.6% of the patients had delivery between 21st and 31st weeks of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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The effect of gestational age at the time of diagnosis on adverse pregnancy outcomes in women with COVID‐19

Aydın

Ünal

Özsoy

2021

J of Obstet and Gynaecol

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Objective: We aimed to investigate the incidence of adverse pregnancy outcomes including preterm birth, preeclampsia (PE), and fetal growth restriction (FGR) in pregnant women with COVID-19 according to the gestational age. Methods: This retrospective study included 167 pregnant women who were hospitalized with confirmed COVID-19. The patients were divided into three groups according to the time of diagnosis as follows: <12 weeks of gestation (first trimester, n = 10), 12-24 weeks of gestation (n = 28), and >24 weeks of gestation (n = 129). Medical records of the patients were reviewed retrospectively and adverse pregnancy outcomes were analyzed. Results: A total of 49 (29.3%) patients had an active COVID-19 infection at the time of delivery, while 118 (70.7%) gave birth after the infection was cleared. Twenty-three patients had preterm birth and the gestational age was <34 weeks in only four of these patients. There was no significant difference in the preterm birth, PE, FGR, HELLP syndrome, and gestational diabetes mellitus among the three gestation groups (p = 0.271, 0.394, 0.403, 0.763, and 0.664, respectively). Four (2.39%) patients required intensive care unit stay. Maternal death was seen in only one (0.59%) patient. Conclusion: Our study showed no significant correlation between the gestational age at the time of COVID-19 infection and the frequency of adverse pregnancy outcomes such as preterm birth, PE, FGR, and gestational diabetes mellitus. However, further studies are needed to draw a firm conclusion on this topic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of gestational age at the time of diagnosis on adverse pregnancy outcomes in women with COVID‐19

Aydın

Ünal

Özsoy

2021

J of Obstet and Gynaecol

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“…[1][2] Since the beginning of the pandemic, pregnancy was thought to be associated with a higher burden of maternal mortality and morbidity compared to the general population, due to the physiologic cardiovascular, respiratory and immunological adaptations. [3][4] Although several cohort studies and systematic reviews evaluating the impact of SARS-COV-2 infection on maternal and perinatal outcomes have been published, [5][6][7][8][9][10][11] the evidence on several aspects of the prenatal management of these pregnancies remains conflicting, including the type and frequency of fetal monitoring, potential risk associated with invasive prenatal diagnosis, timing at delivery and intra-partum monitoring.…”

Section: Introductionmentioning

confidence: 99%

Counseling in maternal–fetal medicine: SARS‐CoV‐2 infection in pregnancy

Mascio

Buca

Berghella

et al. 2021

Ultrasound in Obstet & Gyne

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“…The prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among pregnant women has been reported to be 14-15%, with most (50-90%) women being asymptomatic [1][2][3][4] . Only a small percentage show severe symptoms, mainly during the third trimester of pregnancy 2 ; among these women, there is a higher risk of severe complications and death 5,6 . Nevertheless, most pregnant women who are positive for SARS-CoV-2 are asymptomatic and have a low prevalence of perinatal complications.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound and Doppler findings in pregnant women with SARS‐CoV‐2 infection

Soto-Torres

Hernández‐Andrade

Huntley

et al. 2021

Ultrasound in Obstet & Gyne

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Objectives To describe and compare ultrasound and Doppler findings in pregnant women who were positive for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with findings in those who were SARS‐CoV‐2‐negative, evaluated during the pandemic period. Methods In this retrospective case–control study, we analyzed data from 106 pregnant women who tested positive for SARS‐CoV‐2 at the time of, or within 1 week of, an ultrasound scan between 1 May and 31 August 2020. Scans were either performed for routine fetal evaluation or indicated due to a positive SARS‐CoV‐2 test. Forty‐nine women were symptomatic and 57 were asymptomatic. For comparison, we analyzed data from 103 pregnant women matched for maternal age, parity, body mass index and gestational age at the time of the ultrasound scan. These control women did not report symptoms of SARS‐CoV‐2 infection at the time of the ultrasound scan or at the time of admission for delivery and had a negative SARS‐CoV‐2 test at admission for delivery. Fetal biometry, fetal anatomy, amniotic fluid volume and Doppler parameters, including umbilical and fetal middle cerebral artery pulsatility indices, cerebroplacental ratio and biophysical profile (BPP), were evaluated as indicated. Biometric and Doppler values were converted to Z‐scores for comparison. Our primary outcome, an adverse prenatal composite outcome (APCO) included any one or more of: small‐for‐gestational‐age (SGA) fetus, oligohydramnios, abnormal BPP, abnormal Doppler velocimetry and fetal death. Comorbidities, delivery information and neonatal outcome were compared between the two groups. Results Eighty‐seven (82.1%) women who were positive for SARS‐CoV‐2 had a body mass index > 25 kg/m2. SARS‐CoV‐2‐positive women had a higher prevalence of diabetes (26/106 (24.5%) vs 13/103 (12.6%); P = 0.03), but not of pre‐eclampsia (21/106 (19.8%) vs 11/103 (10.7%); P = 0.08), compared with controls. The prevalence of APCO was not significantly different between SARS‐CoV‐2‐positive women (19/106 (17.9%)) and controls (9/103 (8.7%)) (P = 0.06). There were no differences between SARS‐CoV‐2‐positive women and controls in the prevalence of SGA fetuses (12/106 (11.3%) vs 6/103 (5.8%); P = 0.17), fetuses with abnormal Doppler evaluation (8/106 (7.5%) vs 2/103 (1.9%); P = 0.08) and fetuses with abnormal BPP (4/106 (3.8%) vs 0/103 (0%); P = 0.14). There were two fetal deaths in women who were positive for SARS‐CoV‐2 and these women had a higher rate of preterm delivery ≤ 35 weeks of gestation (22/106 (20.8%) vs 9/103 (8.7%); odds ratio, 2.73 (95% CI, 1.19–6.3); P = 0.01) compared with controls. Conclusions There were no significant differences in abnormal fetal ultrasound and Doppler findings observed between pregnant women who were positive for SARS‐CoV‐2 and controls. However, preterm delivery ≤ 35 weeks was more frequent among SARS‐CoV‐2‐positive women. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.

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Pregnancies recovered from SARS‐CoV‐2 infection in second or third trimester: obstetric evolution

Cited by 9 publications

References 7 publications

The effect of gestational age at the time of diagnosis on adverse pregnancy outcomes in women with COVID‐19

The effect of gestational age at the time of diagnosis on adverse pregnancy outcomes in women with COVID‐19

Counseling in maternal–fetal medicine: SARS‐CoV‐2 infection in pregnancy

Ultrasound and Doppler findings in pregnant women with SARS‐CoV‐2 infection

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