Better analytical technology has been demanded for accurate and rapid determination of trace amounts of chemical compounds, such as marker proteins for disease or endocrine disrupters like dioxin, which might be contained in blood, food and the environment. The study of immunosensors using a quartz crystal microbalance (QCM) has recently focused on conventional detection methods for the determination of chemical compounds together with the development of reagents and processes. This paper introduces the principle of the detection method of QCM immunosensors developed at AIST and its application to the detection of trace amounts of chemical compounds.
Fundamental modes (9 & 50 MHz) and overtone modes of 3rd mode of 33MHz (lOO(3) MHz) and 5th mode of 20 MHz (lOO(5) MHz) of quartz crystal microbalances (QCMs) with high frequencies study to increase the frequency response of QCM gas-sensor.On the fundamental and overtone modes, the ratio of mass sensitivity of QCMs calculated from theory is consistent with that of the experimental results.
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