It is known that the existence of primo vascular system (PVS) including the primo nodes and vessels. However, it is poorly understood the relevant genes in the PVS system both patho- and physiologic condition. Here, we first examined the gene expression in primo vessels (PV) floating in lymphatic endothelium by isolation of PVS and lymphatic vessels (LV) containing PVS. To investigate therapeutic effects, both PV and LV containing PVS were isolated after lipopolysaccharides (LPS) injection and acupuncture electric stimulation (AES) at two acupoints of Joksamni (ST36) and Hapgok (LI04) following LPS. We used reverse transcriptase-polymerase chain reaction (RT-PCR) to examine expression of lymphatic endothelial cell (LEC) markers and inflammatory related genes. We found that LEC markers such as Flt4, Lyve-1, Prox-1, and Pdpn were highly expressed in PV, compared to that of lymphatic endothelium, suggesting pivotal roles of PV in LV under inflammation. Furthermore, lymphatic related genes including Mtf2, Hif1a, Agtr1, and Agtr2 were also overall increased in PV and remarkably increased and these genes except Pparg after AES in two acupoints, implying central role of PV by gene activation.
The existing USB connection type of the clip-type pulsmeter equipped with a Hall sensor and a permanent magnet does not have any error or malfunction to measure the pulse wave. The property of the wireless networking system communicating the pulse wave data through the wireless LAN communication by combination USB with Ethernet and Ethernet to Wi-Fi converting system instead of existing USB connection method was investigated. There are exited that the patient needs to stay at close site of the desktop PC without USB connector and the wireless transfer and receiver networking system has pulse wave measurement SW to receive the pulse wave data. Thus it is expected that the study becomes helpful to measure and transfer the exact pulse wave of the patient in a comfortable pose at close range.
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