The rise and deformation of a gas bubble in an otherwise stationary liquid contained in a closed, right vertical cylinder is investigated using a modified volume-of-fluid (VOF) method incorporating surface tension stresses. Starting from a perfectly spherical bubble which is initially at rest, the upward motion of the bubble in a gravitational field is studied by tracking the liquid–gas interface. The gas in the bubble can be treated as incompressible. The problem is simulated using primitive variables in a control-volume formulation in conjunction with a pressure–velocity coupling based on the SIMPLE algorithm. The modified VOF method used in this study is able to identify and physically treat features such as bubble deformation, cusp formation, breakup and joining. Results in a two-dimensional as well as a three-dimensional coordinate framework are presented. The bubble deformation and its motion are characterized by the Reynolds number, the Bond number, the density ratio, and the viscosity ratio. The effects of these parameters on the bubble rise are demonstrated. Physical mechanisms are discussed for the computational results obtained, especially the formation of a toroidal bubble. The results agree with experiments reported in the literature.

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A lumped parameter model of human cardiovascular-implantable rotary blood pump (iRBP) interaction has been developed based on experimental data recorded in two healthy pigs with the iRBP in situ. The model includes descriptions of the left and right heart, direct ventricular interaction through the septum and pericardium, the systemic and pulmonary circulations, as well as the iRBP. A subset of parameters was optimized in a least squares sense to faithfully reproduce the experimental measurements (pressures, flows and pump variables). Our fitted model compares favorably with our experimental measurements at a range of pump operating points. Furthermore, we have also suggested the importance of various model features, such as the curvilinearity of the end systolic pressure-volume relationship, the Starling resistance, the suction resistance, the effect of respiration, as well as the influence of the pump inflow and outflow cannulae. Alterations of model parameters were done to investigate the circulatory response to rotary blood pump assistance under heart failure conditions. The present model provides a valuable tool for experiment designs, as well as a platform to aid in the development and evaluation of robust physiological pump control algorithms.