Intravenous methylprednisolone followed by oral prednisone speeds the recovery of visual loss due to optic neuritis and results in slightly better vision at six months. Oral prednisone alone, as prescribed in this study, is an ineffective treatment and increases the risk of new episodes of optic neuritis.

Provided data can be used either for the clinician to counsel patients on expected visual outcome or for designing studies to test therapies that might reduce the amount of permanent optic nerve damage due to optic neuritis in high-risk patients.

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Medina. Approximately forty patients a day were Received for publication January 5, 1971 examined for 3 days. At the suggestion of the epidemiologist, the patients were numbered from 150 to 272, so that the memorizing of numbers would be reduced to a minimum. The studies performed on each patient are listed below.