and healing agents, with propolis being a remarkable option. Propolis has been used in popular medicine for a very long time; however, it is not a drug intended for all diseases. Currently, the determination of quality standards of propolis-containing products is a major problem due to their varying pharmacological activities and chemical compositions. The aim of this review is to discuss the use of propolis with emphasis on its anti-inflammatory and healing properties.

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RESUMOObjetivo: Avaliar o conhecimento, a satisfação e autoconfiança de estudantes de cursos de graduação em Enfermagem e Medicina, que participaram da simulação realística. Métodos: Trata-se de estudo quase experimental, exploratório e analítico, sobre a utilização do método de ensino tradicional com aula expositiva e método de ensino com simulação realística. Para coleta dos dados, utilizou-se formulário de caracterização dos participantes, avaliação de conhecimento e Escala de Satisfação dos Estudantes e Autoconfiança na Aprendizagem. Análises descritiva e univariada foram conduzidas. Resultados: A cada método de ensino utilizado houve ganho de conhecimento dos participantes (p<0,001). Em relação à escala de satisfação e autoconfiança, os estudantes demonstraram satisfação e autoconfiança com a simulação realística (p<0,001). A integração do método tradicional com simulação, teoria e prática mostrou-se eficaz para a aquisição e, consequentemente, evolução do conhecimento. Conclusão: A simulação é um método que permite aprimorar o conhecimento do estudante e proporcionar maior satisfação e autoconfiança na aprendizagem. Descritores: Ensino; Exercício de simulação; Triagem; Simulação de paciente. ABSTRACTObjective: To evaluate the knowledge, satisfaction, and self-confidence of undergraduate students of Nursing and Medicine, who participated in the realistic simulation. Methods: This is a quasi-experimental, exploratory, and analytical study about the use of the traditional teaching method with expository class and teaching method with realistic simulation. To collect the data, the participants' characterization form, knowledge assessment and Student Satisfaction Scale and Self-confidence in Learning were used. Descriptive and univariate analyzes were conducted. Results: Every teaching method used there was gain of knowledge of the participants (p <0.001). Regarding the satisfaction and self-confidence scale, students demonstrated satisfaction and selfconfidence with realistic simulation (p <0.001). The integration of the traditional method with simulation, theory, and practice proved to be effective for the acquisition and, consequently, evolution of knowledge. Conclusion: The simulation is a method that allows to improve the knowledge of the student and to provide greater satisfaction and self-confidence in learning. RESUMENObjetivo: Evaluar el conocimiento, la satisfacción y autoconfianza de estudiantes de cursos de graduación en Enfermería y Medicina, que participaron de la simulación realista. Métodos: Se trata de un estudio cuasi-experimental, exploratorio y analítico, acerca del uso del método de enseñanza tradicional con clase expositiva y método de enseñanza con simulación realista. Para la recolección de los datos se utilizó formulario de caracterización de los participantes, evaluación de conocimiento y la Escala de Satisfacción de los Estudiantes y Autoconfianza en el Aprendizaje. Se realizó un análisis descriptivo y univariado. Resultados: A cada método de enseñanza utilizado hubo gano de conocimien...

Our results demonstrate differences between the expression of ECM proteins in the OCs studied. The higher tenascin and fibronectin expression in the capsule of OKCs suggests marked instability in the cystic structure and may contribute to its aggressive behavior.

Wound healing is divided into three phases: inflammatory, proliferative and remodeling. Mast cells participate in all these phases. The aim of the present study was to determine the effects of propolis on the population of mast cells in oral surgical wounds in comparison to the results obtained with dexamethasone. This study was prospective, in vivo, randomized, semiexperimental, quantitative and comparative animal. A circular surgical wound was made on the dorsum of the tongue of 90 hamsters divided into three experimental groups: topical application of 30% propolis alcoholic extract (Group 1); 0.1% dexamethasone in orabase cream (Group 2); and orabase cream alone (Group 3). Applications were performed every 12 h throughout the experiment. The postoperative times for killing of the animals were 1, 3, 7, 14 and 28 days. The Student's t test for independent samples was employed in the statistical analysis. In the inflammatory phase of healing, propolis caused a greater reduction in the number of mast cells on the edge and in the central region of the surgical wound in comparison to dexamethasone. Moreover, the number of mast cells on day 1 was lower in the central region of the wounds treated with the orabase cream alone in comparison to dexamethasone. In conclusion, the anti-inflammatory action of propolis mediated by mast cells was more effective than dexamethasone in the inflammatory phase of healing.

Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis.Objective To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.

Basosquamous carcinoma (BSC) is a rare aggressive epithelial neoplasm with features of both basal cell carcinoma and squamous cell carcinoma, with a tendency toward local recurrence and a propensity for lymph node and distant metastases. The aim of the present study was to report the case of a 63-year-old Caucasian male with BSC in the auricular region.

Background. Fibroblasts on the edges of a surgical wound are induced to synthesize collagen during the healing process which is known as fibroplasia.Objective. The aim of this study was to determine the effect of the application of different substances on fibroplasia of cutaneous surgical wounds on rats.Materials and Methods. 48Wistarrats were divided into three groups. A surgical wound 1 cm in diameter and 1  mm in depth was created on the dorsum of each animal. The surgical wounds were submitted to the topical application of an alcoholic extract of 30% propolis, 70% alcohol, or 0.001% dexamethasone in a cream base every 12 hours. The animals were sacrificed three, seven, 14, and 28 days postoperatively. The specimens were histologically processed and stained with Masson’s trichrome. The assessment of fibroplasia was performed using a scoring system: (1) 5 to 25% collagen deposition; (2) 26 to 50% collagen deposition; (3) 51 to 75% collagen deposition; (4) more than 75% collagen deposition.Results. There were statistically significant differences in collagen deposition between the substances at all postoperative evaluation times.Conclusion. Propolis and alcohol promoted greater collagen deposition in surgical wounds than dexamethasone.