Tenascin and fibronectin expression in odontogenic cysts

Oliveira, Maurício da Silva Lorena de; Miranda, João Luiz de; Amorim, Rivadávio Fernandes Batista de; Souza, Lélia Batista De; Freitas, Roseana de Almeida

doi:10.1111/j.1600-0714.2004.00212.x

Cited by 29 publications

(39 citation statements)

References 46 publications

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“…Murata et al [30] and Poomsawat et al [13] suggested that AOT cells, like pre-ameloblasts, are able to synthesize ECM proteins due to the presence of Wbronectin inside the luminal spaces of duct-like structures. Although this latter Wnding could not be veriWed in the present study, the focal positivity for Wbronectin in epithelial cells of AOT conWrms the capacity of these cells to synthesize this glycoprotein [13,29]. Further analysis of our results showed that Wbronectin expression is more intense at the epithelial-mesenchymal interface of both solid ameloblastomas and AOT, showing a linear and discontinuous distribution in most cases, a fact also reported by Heikinheimo et al [28].…”

Section: Discussionsupporting

confidence: 60%

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Medeiros

Nonaka

Galvão

et al. 2009

Eur Arch Otorhinolaryngol

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This study evaluated the expression of Wbronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the diVerences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate Wbronectin expression in the stroma. Solid ameloblastomas showed intense expression of Wbronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of Wbronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.

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Section: Discussionsupporting

confidence: 60%

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Medeiros

Nonaka

Galvão

et al. 2009

Eur Arch Otorhinolaryngol

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“…There are few reports available in the literature regarding tenascin expression and its role in odontogenic tumors (4,9,20). In our study, tenascin positivity was more prominent in the KOT connective tissue wall compared to the RCs and DCs.…”

Section: Discussionsupporting

confidence: 44%

Immunohistochemical Analysis of Matrix Metalloproteinases-1,-9 and Tenascin in Odontogenic Lesions

et al. 2014

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Ameloblastoma (ABL) and keratocystic odontogenic tumor (KOT) are benign odontogenic tumors with local aggressive behaviors. The purpose of our study was to compare MMP-l, MMP-9 and tenascin staining patterns between "aggressive" ameloblastoma / keratocystic odontogenic tumors and "nonaggressive" radicular cysts (RC)/ dentigerous cysts (DC). Ameloblastoma, keratocystic odontogenic tumor, radicular cyst (RC) and dentigerous cyst (DC) specimens were chosen from the archives of Gazi University Faculty of Dentistry, Department of Oral Pathology, and immunohistochemically stained with MMP-l, -9 and tenascin antibodies. The immunohistochemical expressions were noted and statistically analyzed. The ABLs and KOTs showed significantly higher MMP-l and -9 positivity than the RCs and DCs (p

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“…ECM proteins have been detected in several odontogenic cysts and tumors, 7,8,[17][18][19] but no investigation has explored the relationship between collagen IV, MMPs, and TIMPs in odontogenic cysts and tumors.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors

Henriques

Vasconcelos

Galvão

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective. The aim of this study was to evaluate the immunohistochemical expression of collagen IV, matrix metalloproteinase (MMP) 9 and tissue inhibitor of MMP (TIMP) 2 in dentigerous cysts (DCs), radicular cysts (RCs), keratocystic odontogenic tumors (KOTs), and ameloblastomas. Study design. Twenty cases of DCs, 20 RCs, 20 KOTs, and 20 ameloblastomas were selected and analyzed by immunohistochemistry. Results. Most DCs and RCs showed continuous and Ͼ50% staining for collagen IV in the basement membrane of the epithelium, whereas predominantly discontinuous thin and Յ50% staining was observed in KOTs and ameloblastomas, with a significant difference in staining percentage (P Ͻ .001). MMP-9 was diffusely distributed and localized in both epithelial and mesenchymal cells of all of the lesions analyzed. The staining percentage was higher in the epithelium (P ϭ .058) and mesenchyme (P ϭ .005) of KOTs and ameloblastomas. Moreover, the distribution pattern, location, and percentage of expression of TIMP-2 were similar in the lesions studied, except for ameloblastoma, with a significant difference in staining percentage (P Ͻ .001).Conclusion. These results demonstrate that the interaction between collagen IV, MMP-9, and TIMP-2 is an important factor for the establishment of differences in the biologic behavior of the odontogenic cysts and tumors studied. Factors related to the epithelial and mesenchymal components participate in the regulation of the growth of odontogenic cystic lesions and tumors. 1 The altered expression of specific proteins of the extracellular matrix (ECM), associated with the exuberant presence of matrix metalloproteinases (MMPs) and the absence of expression of metalloproteinase inhibitors (TIMPs), may influence the behavior of these lesions. In the case of tumors, this situation contributes to the growth and higher aggressiveness of the tumor. 2 The odontogenic keratocyst, recently reclassified as keratocystic odontogenic tumor (KOT), 3 is known for its aggressive nature and high rate of recurrence, especially compared with other odontogenic cysts. 4 Ameloblastoma is a locally aggressive benign epithelial odontogenic tumor with a marked invasion potential that results in multiple recurrences after enucleation and curettage. 5 In contrast, dentigerous (DC) and radicular (RC) cysts show an indolent behavior and rarely recur after surgical removal. KOT presents a cystic structure similar to that of DC and RC, but its invasive and destructive growth is similar to that of ameloblastoma. 6 KOT, ameloblastoma, DC, and RC show distinct evolutions and biologic behaviors. In view of this fact, a growing number of studies have tried to identify

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Tenascin and fibronectin expression in odontogenic cysts

Abstract: Our results demonstrate differences between the expression of ECM proteins in the OCs studied. The higher tenascin and fibronectin expression in the capsule of OKCs suggests marked instability in the cystic structure and may contribute to its aggressive behavior.

Cited by 29 publications

References 46 publications

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Immunohistochemical Analysis of Matrix Metalloproteinases-1,-9 and Tenascin in Odontogenic Lesions

Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors

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