A B S T R A C TPorcine transmissible gastroenteritis virus (TGEV) is one of the major etiological agents of viral enteritis and fetal diarrhea in suckling piglets. In this study, a TGEV JS2012 strain was isolated from the feces of piglets in Jiangsu Province, China. The phylogenetic analysis showed that TGEV JS2012 was placed between the Purdue and the Miller clusters. Analysis of recombination confirmed that TGEV JS2012 is a natural recombinant strain between Miller M6 and Purdue 115. Similar to Miller M6, virulent Purdue and China strain TS, in S gene the JS2012 maintained genetic integrity and the characteristics of the TGEV virulent strains. In vivo, TGEV JS2012 caused 100% mortality in newborn piglets, indicating the strong pathogenicity of this isolate. These results reveal that the JS2012 is a novel natural recombinant TGEV with high virulence. Our findings provide valuable information about genetic diversity and infection mechanism of the coronavirus family.

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This paper describes a synthesis method of uniformly excited unequally spaced planar array with maximum beam collection efficiency (BCE) based on Chaotic Particle Swarm Optimization (CPSO) algorithm. And here the multiple optimization constrains include the number of array elements, the aperture, the minimum element spacing, and the maximum sidelobe level (SLL) outside the receiving region. Through this method, feeding network of the array becomes simple and compact. Effectiveness of the proposed method is validated by comparing the simulation results obtained in this paper to those reported in the state-of-the-art literature.Index Terms-Antenna arrays, microwave power transmission, chaotic particle swarm optimization, solar power satellite.

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This paper proposes an electromechanical co-design method of a structurally integrated antenna to simultaneously meet mechanical and electrical requirements. The method consists of three stages. The first stage involves finishing an initial design of the microstrip antenna without a facesheet or honeycomb, according to some predefined performances. Subsequently, the facesheet and honeycomb of the structurally integrated antenna are designed using an electromechanical co-design optimization. Based on the results from the first and second stages, a fine full-wave electromagnetic model is developed and the coarse design results are further optimized to meet the electrical performance. The co-design method is applied to the design of a 2.5 GHz structurally integrated antenna, and then the designed antenna is fabricated. Experiments from the mechanical and electrical performances are conducted, and the results confirm the effectiveness of the co-design method. This method shows great promise for the multidisciplinary design of a structurally integrated antenna.

Pathogenic coronaviruses represent a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified several small-molecule inhibitors that potently block the replication of the newly emerged severe acute respiratory syndrome virus 2 (SARS-CoV-2). Two compounds, nitazoxanide and JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with an EC50 of 4.90 μM and 0.69 μM, respectively, with specificity indices of greater than 150. Both inhibitors had in vitro antiviral activity in multiple cell types against some DNA and RNA viruses, including porcine transmissible gastroenteritis virus. In an in vivo porcine model of coronavirus infection, administration of JIB-04 reduced virus infection and associated tissue pathology, which resulted in improved body weight gain and survival. These results highlight the potential utility of nitazoxanide and JIB-04 as antiviral agents against SARS-CoV-2 and other viral pathogens.

This paper describes the synthesis method of uniformly excited unequally spaced planar array with maximum beam collection efficiency (BCE, i.e., the ratio between the power radiated over a target region and the whole transmitted power) using Particle Swarm Optimization (PSO) algorithm. Based on this method, feeding network of the arrays becomes simple and compact and is easy to implement. And here the multiple optimization constrains include the number of elements, and the array aperture. Comparison of representative example is presented, and the results show that an enhancement of BCE and a depression of the sidelobe level outside of the receiving region (CSL) can be obtained through the proposed method.