The transcription factor NF-B activates a number of genes whose protein products are proinf lammatory. In quiescent cells, NF-B exists in a latent form and is activated via a signal-dependent proteolytic mechanism in which the inhibitory protein IB is degraded by the ubiquitinproteasome pathway.

SignificanceWe project drought losses in China under global warming of 1.5 °C and 2.0 °C. To assess future drought losses, we project the regional gross domestic product under shared socioeconomic pathways instead of using a static socioeconomic scenario. We identify increasing precipitation and evapotranspiration patterns. With increasing drought intensity and areal coverage across China, drought losses will increase considerably. The estimated losses in a sustainable development pathway at 1.5 °C warming will be 10 times higher than in the reference period 1986–2005 and three times higher than in 2006–2015. Yet, climate change mitigation, limiting the temperature increase to 1.5 °C, can considerably reduce the annual drought losses in China, compared with 2.0 °C warming.

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NE could stimulate pancreatic cancer cell proliferation, migration and invasion through a β-AR-dependent activation of P38/MAPK pathway involved.