The present study investigates the anti-spermatogenic potential of ethanolic extract of Matricaria recutita a plant belonging to Asteraceae family. The effects of an ethanolic extract of the Matricaria recutita on spermatogenesis, histology of testis and level of testosterone were examined in control and experimental groups. Results showed that Matricaria recutita extract did not cause any changes in body weight, but significantly decreased the testis weight (p<0.05). The sperm motility and the epididymal sperm counts and serum testosterone levels of rats treated for 56 days were significantly reduced (p<0.05). There were various degrees of damage to the seminiferous tubules including; disorganized germinal epithelium, degenerated and necrotic cells and reduction in the diameter of seminiferous tubules. It can be concluded that that alcoholic extract of Matricaria recutita has antispermatogenic properties in adult male rats through its compounds and it may be useful to regulate spermatogenesis and male fertility.
Aims: Wound healing is a complex physiological process involves a series of successive stages of hemostasis, inflammation, proliferation, and regeneration. This study aimed to investigate the effect of hydroalcoholic extract of Brassica oleracea L. (var. capitata) leaves in comparison with Phenytoin on epithelial layer healing and the holes in the skin of mice. Materials & Methods: This study was done on 40 male NIH Mice between 25-30gr. Animals were randomly divided into 4 groups (n=10). Negative control group received saline, positive control group administrated with 1% Phenytoin and treated groups received 10% and 20% hydroalcoholic extract twice a day until closing holes. Macroscopic and microscopic analysis was performed on days 1, 4, 7, 12 and 15. Statistical analysis was done by SPSS 16 software and Tukey test. Findings: A significant reduction was observed in average size of holes in 20% hydroalcoholic extract treated group compared to the negative control 10% extract at day 7 (p=0.001). There was a significant reduction in average size of holes in 20% extract group compared to 10% extract and negative control groups at day 12. (p=0.007). The skin holes in 20% extract group were closed earlier than the other groups. Epithelial thickness was increased in 20% extract group from 7th day the much faster than other groups. Conclusion: Brassica oleracea L. (var. capitata) has the same effect of phenytoin in healing of rapid closure of holes and proliferation of epithelial cells.
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