Development of a large-scale enantioselective synthesis of a lead compound containing a 3-aryl-3-trifluoromethyl-2-aminopropanol core is described. A single isomer of 3,3-disubstituted acrylic acid derivative was prepared via Perkin condensation or Horner-Wadsworth-Emmons olefination, followed by hydrolysis. The acid was converted to a chiral acryloxazolidinone derivative. Hydrogenation of the latter on Pd/C in the presence of MgBr 2 proceeded via a chelation-controlled conformation to yield the desired isomer with high selectivity. Subsequent Evans azidation, hydrogenation, reductive cleavage of the chiral auxiliary, and sulfonylation afforded the target compound as a single isomer in high overall yield.
MIL-101 is a typical metal-organic framework. Mil-101, like the other metal-organic frameworks (MOFs) is a material with high porosity, large surface area, adjustable micro-pore size, and easy functional structure. Contrary to the most MOFs, Mil-101 has a high hydrothermal stability. All of the characteristics collectively make MIL-101 a good candidate for a catalyst support. In this paper, the synthesis methods of MIL-101 materials have been reviewed. It is pointed out that the hydrothermal synthesis method has many problems such as complicated process, many organic waste liquid and low yield. The room temperature fast synthesis method has the potential to provide industrialized production of MIL-101 with its unique advantages.
Development of a scalable synthesis of WAY-315193 is described. Use of LiHMDS as a base and Ti(O-i-Pr) 4 as a Lewis acid was optimal for efficient and reproducible addition of indolinone anion to epoxyalcohol. Conversion of indolinone diol to indolinone aminoalcohol was achieved via monotosylationmethylamination. The possibility of selective formation of the amidine side product, as well as its utilization for alternative selective preparation of the target aminoalcohol, was demonstrated.
With the continuous consumption of fossil energy and non-renewable, countries all over the world pay more and more attention to the use of renewable energy, among which Denmark, Japan, Germany and so on are among the best. Based on the basic national conditions and the energy development situation of our country, the utilization of renewable energy in our country is also promoted to the national strategic position. Experience shows that large-scale renewable energy access to the power grid system can not only meet the electricity demand of industrialized countries. Moreover, the safe and stable operation of the power grid can be realized by advanced technical means. Through the analysis of some advanced technology and equipment research in the development and utilization of renewable energy in foreign power grid, in order to improve the repeatability of our country, The level of development and utilization of raw energy.
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