Synthesis of Metal Organic Framework Material MIL-101

Zhang, Xiaolin; Li, Fangqin; Ren, Jianxin; Feng, Hao; Hou, Xingsong; Ma, Chuang

doi:10.1088/1755-1315/295/3/032022

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Zhang et al used the same method for synthesizing NH 2 ‐MIL‐101 with a suitable crystal growing; as we followed the same synthesis strategy, it was hoped to get the same characteristics in this study. [ 44 ] Post‐synthesis loading process in EtOH was used for trapping Pt‐CUR complex into MIL framework cavities. Because the NH 2 ‐MIL‐101 is a mesoporous structure with a large specific area and pore cavity, this loading method is one of the best‐studied methods available for drug loading in NH 2 ‐MIL‐101.…”

Section: Resultsmentioning

confidence: 99%

Hyaluronic acid targeted metal organic framework based on iron (III) for delivery of platinum curcumin cytotoxic agent to triple negative breast cancer cell line

Moradi

Aliomrani

Tangestaninejad

et al. 2022

Applied Organom Chemis

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Platinum‐based drugs are an essential class of chemotherapy drugs in breast cancer. However, suffer from side effects and drug resistance; structural changes and applying drug carriers can lead to new drug candidates in this class. The metal‐organic frameworks (MOFs) as porous carriers have recently attracted much attention in drug delivery. In this study, for the first time, hyaluronic acid (HA)‐targeted MOF (NH2‐MIL‐101 (Fe)) nanoparticles (Pt‐CUR@MIL@HA NPs) were evaluated in delivery of platinum‐curcumin (Pt‐CUR) prodrug to the MDA‐MB‐231 triple‐negative breast cancer cell line; in this regard, the cytotoxicity, ROS production, and cellular uptake of designed NPs have been studied. Different analysis methods confirmed chemical structures, the prepared NPs had a uniform morphology, and the hydrodynamic size of the optimized non‐targeted loaded particles increased to about 252 nm with a zeta potential of +26.9 mV, after targeting with HA, the size increased to 310 nm, and the zeta potential changed to −28 mV. Based on TGA and atomic absorption (ICP‐MS) results, the drug loading percent was determined to be about 30%–35%. Drug release from the HA targeted Pt‐CUR@MIL@HA system in the neutral condition was slow and sustained, and after 36 h, a maximum of 60% of the drug was released, but in acidic conditions, the release was increased, and by 18 h, the release was about 80%. The cytotoxicity of MOF NPs containing Pt‐CUR was more significant than that of the free drug, and HA targeted has resulted in more cellular uptake than the non‐targeted NPs. In conclusion, these new MOF‐ based HA‐coated NPs of PT‐CUR can be introduced to pre‐clinical researches after completing in vitro and in vivo studies.

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Section: Resultsmentioning

confidence: 99%

Hyaluronic acid targeted metal organic framework based on iron (III) for delivery of platinum curcumin cytotoxic agent to triple negative breast cancer cell line

Moradi

Aliomrani

Tangestaninejad

et al. 2022

Applied Organom Chemis

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“…The Sonochemical method of MOF synthesis has been applied in the synthesis of pure crystals of MOF-177 and MOF-5 having a size of 5-20 µm and 5-25 µm, respectively [37,48,49]. Table (1) presents the limitations and advantages of all the methods of synthesis of MOFs described above [50][51][52][53]…”

Section: Sonochemistry Methodsmentioning

confidence: 99%

Carbon (IV) oxide adsorption efficiency of functionalized HKUST-1, IRMF-1, and UiO-66 metal organic frameworks

Abdullahi Moyosore,

Ahmad,

Muhammad Alif Muhammad Latif

et al. 2024

J. Nig. Soc. Phys. Sci.

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The ever-increasing consumption of fossil fuels to meet up with the global economic and industrial energy needs has led to climatic change due to uncontrollable emission of a major greenhouse gas (CO2). As a way of mitigating the amount of CO2 in the atmosphere, search for effective and efficient solid adsorbent has been at the front burner of current scientific research. A class of solid adsorbent known as metal organic frameworks (MOFs) have demonstrated immense potentials for CO2 adsorption due to its porous, high thermal and chemical stability, high versatility and ease of production. Upon functionalization, the adsorption efficiency of this class of materials was found to improve tremendously. In this review, the CO2 capture and sequestration potentials of three MOFs (UiO-66, HKUST-1, and MOF-5) and their composites were investigated in the search for economical, stable, and highly selective novel adsorbents for CO2 adsorption.

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“…Currently, various MOFs have been successfully constructed by using microwave-assisted synthesis for drug delivery 106–113 (Fig. 2).…”

Section: The Synthesis Of Mofs Used In Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

Xing,

Xu,

Zhou

et al. 2024

Nanoscale

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Synthesis of Metal Organic Framework Material MIL-101

Cited by 5 publications

References 10 publications

Hyaluronic acid targeted metal organic framework based on iron (III) for delivery of platinum curcumin cytotoxic agent to triple negative breast cancer cell line

Hyaluronic acid targeted metal organic framework based on iron (III) for delivery of platinum curcumin cytotoxic agent to triple negative breast cancer cell line

Carbon (IV) oxide adsorption efficiency of functionalized HKUST-1, IRMF-1, and UiO-66 metal organic frameworks

Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

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