Selective functionalization of ubiquitous CÀ H bonds of molecules would provide novel retrosynthetic insights and powerful tools for the rapid construction of molecular complexity. In this context, Cp*Ir(III) complexes have exhibited versatile reactivity towards the selective conversion of CÀ H bonds, with key features that include the use of readily transformable raw materials, great selectivity (chemo-, stereo-and regio-), high efficiency, mild reaction conditions and they enable late-stage modification of complex molecules. Recently, Cp*Ir(III) catalysis has achieved a broad range of reactions such as multiple dehydrogenations and stereoselective CÀ X bond formations. These advancements are valuable to organometallic chemists and enable the efficient synthesis of functionalized architectures.
This review article provides an overview of the recent progress in the transformations of anthranils, which have emerged as versatile building blocks in the assembly of various C–N bonds and medicinally active heterocyclic systems.
A method for the synthesis of diverse polysubstituted quinolines from readily available acrylic acids and anthranils has been developed. The weakly coordinating −COOH directing group, which can be tracelessly removed in the cascade cyclization, is essential for this reaction. Diverse polysubstituted quinolines were obtained under mild reaction conditions with simple H 2 O and CO 2 as byproducts. More importantly, 1,2,3,4-tetrahydroacridine, which is the core skeleton of tacrine (an Alzheimer's disease drug), was conveniently synthesized.
The exploration of synthetic versatile, while weak coordinated amine derivatives enabled regioselective C‒H functionaliza-tion, remained challenging due to the elusive achievement of reactivity and selectivity simultaneously. Herein, with the assis-tance...
Nitrosoarenes are readily available and highly reactive, making them promising building blocks in organic chemistry. The recent development of radical conversions of nitrosoarenes provides an alternative and powerful platform for...
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