No abstract

This protocol provides a unique and innovative approach to the construction of α-tert-butylperoxy-β-dichloromethyl alkanes, employing CHCl3 as an alkylating reagent to provide a –CHCl2 group, and TBHP as an oxidant to provide an α-tBuOO group.

The exploration of synthetic versatile, while weak coordinated amine derivatives enabled regioselective C‒H functionaliza-tion, remained challenging due to the elusive achievement of reactivity and selectivity simultaneously. Herein, with the assis-tance...

No abstract

An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is described. This reaction features a cheap catalyst, a green oxidant, and readily available starting materials, which make the overall synthesis applicable in the quick access to relevant pharmaceutical molecules with imidazole derived heterocycles.

N-acylation of arylamines with di-and trialkyl amines has been reported. This approach provides a general synthesis of aromatic amides by an alkyl transfer through cleavage of the CÀ N bond, and acts as a model for N-dealkylations and N-acylations. Additionally, the synthesis is a promising method towards amidation reactions, wherein di-and trialkyl amine derivatives are employed as sources of acyl carbon atoms and tert-butyl hydroperoxide is employed as the oxygen source of the acyl group.

No abstract

The palladium-catalyzed C3-cyanation of indoles via direct C–H functionalization was achieved utilizing CH3CN as the cyanide source through transition-metal-catalyzed C–CN bond cleavage.