No abstract

This protocol provides a unique and innovative approach to the construction of α-tert-butylperoxy-β-dichloromethyl alkanes, employing CHCl3 as an alkylating reagent to provide a –CHCl2 group, and TBHP as an oxidant to provide an α-tBuOO group.

The exploration of synthetic versatile, while weak coordinated amine derivatives enabled regioselective C‒H functionaliza-tion, remained challenging due to the elusive achievement of reactivity and selectivity simultaneously. Herein, with the assis-tance...

No abstract

An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is described. This reaction features a cheap catalyst, a green oxidant, and readily available starting materials, which make the overall synthesis applicable in the quick access to relevant pharmaceutical molecules with imidazole derived heterocycles.