In engineering design, customers usually provide product requirements in the form of a natural language while computer-aided design systems may prefer more formal and structured specifications. In this paper, a formalisation process is proposed to transform product requirements from its natural language descriptions to a formal specification. The formal specification is based on the product environment and the formulation of design problem, which identifies the components included in a design problem in terms of the product environment. Through the lexical, syntactic, and structure analysis of natural language descriptions of a design problem, the formalisation process identifies the product to be designed, its environment components, and their relations. A software prototype is developed to validate the formalisation process. An example of rivet setting tool design shows that both the formalisation process and software prototype are feasible.
In fermentation process, substrate concentration control is important in increasing product concentration, productivity and substrate yield so as to decrease the production cost. But, the feedback control of substrate concentration is difficult for the lack of sensor for online measurement of substrate concentration. In order to overcome above problem, dissolved oxygen (DO) stat strategy was developed for feedback control of glucose feeding in fedbatch fermentation using the abrupt increase of DO as the indicator for glucose depletion and glucose feeding. In this research, the DO stat control strategy for bioreactor control will be developed and the control process will be simulated. The simulation results indicate that the DO stat strategy is effective in glucose feeding control.
Bioprocess automation is developing fast for the reasons of quality control, production cost reduction et. al.. Bioreactor is the central equipment of bioprocess. Construction of computer controlled bioreactor is need for bioprocess automation. In this research, a two level hierarchical structure computer control bioreactor system is designed and constructed. The lower level plays the major role of set-point feedback control of process variables and the higher level plays the major role of graphical human interface and biological mathematical model solution. This control system has advantages of high reliability and flexibility than the single level digital control system, and has plenty of functions and high practicality compared with a normal commercial one.
Fermentation process using recombinant strain for production of recombinant protein is widely used in commercialization of the biotechnologies. The continuous stirred tank reactor (CSTR) is a typical microbial cultivation method, has the major advantage of high productivity. Mathematical modeling and simulation is useful for analysis and optimization of the CSTR fermentation process. Most of the mathematical models developed for CSTR are black box models without information of the intracellular dynamics and regulations. In this research, a mathematical model is built based on gene regulation for recombinant protein production using CSTR, and simulation is made using this model.
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