Near-infrared (NIR) spectroscopic imaging technology provides a new modality for measuring changes in total hemoglobin concentration (HbT) and blood oxygen saturation (SO2) in human tissue. The technology can be used to detect breast cancer because cancers may cause greater vascularization and greater oxygen consumption than in normal tissue. Based on the NIR technology, ViOptix, Inc., has developed an optical device that provides two-dimensional mapping of HbT and SO2 in human tissue. As an adjunctive tool to mammography, the device was preliminarily tested in a clinical trial with 50 mammogram-positive patients at the Massachusetts General Hospital. The results of the clinical trial demonstrate that the device can reach as much as 92% diagnostic sensitivity and 67% specificity in detecting ductal carcinoma. These results may indicate that the NIR technology can potentially be used as an adjunct to mammography for breast cancer detection to reduce the number of biopsies performed.
Using a near-infrared optical device developed by ViOptix, Inc., a clinical study on post-operative non-invasive monitoring of fmger blood perfusion has been conducted for 48 patients undergoing digital replantation at the California Pacific Medical Center. The study showed that non-survival digits have their tissue oxygen saturation (St02) values significantly lower than those for the controls in general, but survival digits did not. Further, the St02 values can be used to defme a survival index, in terms of which a digit survival criterion was tentatively suggested. Applying the criterion to the 64 digits (with 3 of them non-survival) involved in the clinical study, the sensitivity and the specificity were high. Therefore the device may have potential to be used in post-operative monitoring for digit replantation.
It is well known that the relation between the partial pressure of oxygen in blood (PO 2 ) and the hemoglobin oxygen saturation in blood (SO 2 ) is given by the oxyhemoglobin dissociation curve. In this study, we investigate if a similar relation exists in tissue. The PO 2 in tissue was approximated by the transcutaneous partial pressure of oxygen (TcPO 2 ) measured by TCM3 TM Transcutanous pO 2 /pCO 2 Monitoring System; and the SO 2 in tissue (StO 2 ) was measured by ODISsey TM Tissue Oximeter. The study showed that the TcPO 2 versus StO 2 relation is similar to the dissociation curve in blood, as expected.Keywords: Tissue oxygen saturation, near infrared spectroscopy, transcutaneous partial pressure of oxygen, the oxyhemoglobin dissociation curve.
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