Near infrared/ultrasound dual modal imaging for breast cancer detection

A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions

“…The difficulty comes from the significant tissue heterogeneities and interpatient variations that may exceed the characteristic difference between benign and malignant tumors [ 22 - 25 ]. To overcome this difficulty, some investigators studied tissue dynamic characteristics in response to physiologic, chemical, and mechanical stimuli [ 27 - 30 , 32 ]. Other investigators derived relative diagnostic criteria by calculating differential oxygen and hemoglobin parameters between the tumor and the reference tissue in the contralateral, cancer-free breast [ 20 ].…”

“…As previously described [ 31 , 32 , 34 ], a mobile experimental apparatus was developed that consists of a laptop computer, a portable clinical ultrasound system (Terason 2000; Teratech, Burlington, MA, USA), and a continuous wave-type, portable NIR tissue imager (P-Scan; ViOptix Inc., Fremont, CA, USA). The current system setup is shown in Figure 1 .…”