Comparison of TcPO 2 and StO 2 using the blood oxygen dissociation curve

Wright, Lesley C.; Makhratchev, Marina; Yarbrough, Amy; Elmandjra, Mohamed; Mao, Jian‐min

doi:10.1117/12.640174

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…Diffuse reflectance from two wavelengths (660 and 740 nm) is utilised to algorithmically generate a StO 2 map for each imaged pixel (Figure 5). It is known from previous studies that an empirical relationship exists between TcPO 2 and StO 2 19,20 . The readings were segmented into 3 categories: Normal (>90 for StO 2 ;>55 mmHg for TcPO 2 ), Concerning (80–90 for StO 2 and 40–55 mmHg for TcPO 2 ), and Low (<80 for StO 2 and <40 mmHg for TcPO 2 ) in order to compare the StO 2 readings with TcPO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…It is known from previous studies that an empirical relationship exists between TcPO 2 and StO 2 . 19,20 The readings were segmented into 3 categories: Normal (>90 for StO 2 ;>55 mmHg for 3). A p-value of p >0.05 from the statistical test led to the conclusion that there was no difference between the oxygenation measurements between Illuminate Pro Max and Perimed Periflux 5000 across various wound grades at various wound proximities (Figure 6).…”

Section: Tissue Oxygenation Measurement Using Illuminate Pro Maxmentioning

confidence: 99%

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Multimodal imaging device to comprehensively assess infection, oxygenation, and wound analytics—A pilot study

Kesavan,

Sasikumar

2024

Wound Repair Regeneration

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Wound analytics, infection detection, and oxygenation measurement are the three critical prerequisites for appropriate wound care. Although devices that rapidly detect the above‐mentioned parameters independently exist, there is no single point‐of‐care device that is enabled with all the three functionalities. Through this study, we are introducing and evaluating the performance of Illuminate Pro Max—a novel, rapid, hand‐held non‐contact, point‐of‐care multimodal imaging device that is equipped to measure the three wound assessment parameters. Here, a total of 60 diabetic foot ulcer patients were imaged using Illuminate Pro Max to detect bioburden and measure StO2 levels and wound dimensions (size and depth). The results were further evaluated against the current gold standard technique for each parameter, that is, culture test to detect bioburden, a transcutaneous oxygen pressure (TcPO2) measuring device—Perimed Periflux 5000 to measure oxygenation, and paper ruler to measure wound size. Culture tests reported 42 samples as infection‐positive and 18 samples as infection‐negative. On comparing with the culture report, the device showed 88% sensitivity and 86% PPV in detecting the bioburden. Wound dimensions (length and width) were comparable with the paper scale measurements. Wound depth was also reported by the device. The StO2 map generated by the device depicted the tissue oxygenation levels in various regions of the wound. In conclusion, this novel, comprehensive point‐of‐care multispectral imaging device can be an effective tool for rapid wound assessment which can help in prompt treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Tissue Oxygenation Measurement Using Illuminate Pro Maxmentioning

confidence: 99%

Multimodal imaging device to comprehensively assess infection, oxygenation, and wound analytics—A pilot study

Kesavan,

Sasikumar

2024

Wound Repair Regeneration

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“…This difference will be pronounced during for example a breathing provocation with oxygen. While breathing 100% oxygen, the oxygen saturation parameter will rapidly reach a plateau where all possible oxygen is bound to hemoglobin, while the tcpO2 value will continue to increase [120]. Also it should be noted that the tcpO2 electrode heats the skin, causing a local hyperemia with an increased blood flow and oxygen pressure as a result.…”

Section: The Output Parametersmentioning

confidence: 99%

Model-based quantitative assessment of skin microcirculatory blood flow and oxygen saturation

Jonasson¹

2016

Linköping Studies in Science and Technology. Dissertations

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The microcirculation, involving the smallest vessels in the body, is where the oxygen transport to all tissue occurs. Evaluating microcirculatory parameters is, therefore, important and involves the quantification of oxygen content of red blood cells (RBCs), the amount of RBCs and their speed.Diffuse reflectance spectroscopy (DRS) can be used to estimate blood oxygen saturation and fraction of RBCs in tissue since oxygenated and deoxygenated blood have different light absorption characteristics. By illuminating the skin with white light and detecting the spectrum of the backscattered light, tissue absorption and scattering can be assessed. Laser Doppler flowmetry (LDF) is a technique to measure blood flow in tissue. When laser light encounter moving objects in tissue, i.e. RBCs, the light is Doppler shifted, which can be detected and used to calculate tissue perfusion (the fraction of moving RBCs times their speed). With a small distance between light source and detector, both techniques measure superficially where most vessels are microcirculatory vessels. Photon transport in tissue can be simulated with Monte Carlo techniques and the simulations form the basis of modeled DRS and LDF spectra. The estimated microcirculatory parameters are given by the model that best describe measured DRS and LDF data.This thesis describes the development and the evaluation of an optical method to simultaneously measure oxygen saturation, RBC tissue fraction and speed resolved perfusion in absolute units by integrating DRS and LDF. By combining DRS and LDF into one system with a common tissue model, the two modalities can benefit from each other's strengths. Different calibration methods and model assumptions for the system were evaluated in optical phantoms and in skin measurements. A simple calibration method with two detector distances for DRS was found adequate to accurately estimate absorption and scattering in optical phantoms. It was also necessary to model blood located in vessels, rather than homogeneously distributed in the skin, to obtain accurate parameter estimates. The system was evaluated in healthy subjects during standard provocations, where the parameters were in agreement with other studies and followed an expected pattern during the provocations. In patients with diabetes type 2, tissue fraction of RBCs and nutritive blood flow were reduced in baseline compared to healthy controls. These differences were not related to prevalence of microalbuminuria, a marker sign of microvascular complications in the kidneys.A combined system with DRS and LDF enables a more comprehensive assessment of the microcirculation by measuring oxygen saturation, RBC tissue fraction and speed resolved perfusion simultaneously and in absolute units. This system has clinical potential to assist in the evaluation of the microcirculation both in healthy and diseased individuals. POPULÄRVETENSKAPLIG SAMMANFATTNINGMikrocirkulationen innefattar de minsta kärlen i kroppen och det är här syretransporten till all vävnad i kroppen sker. ...

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Comparison of TcPO 2 and StO 2 using the blood oxygen dissociation curve

Cited by 2 publications

References 9 publications

Multimodal imaging device to comprehensively assess infection, oxygenation, and wound analytics—A pilot study

Multimodal imaging device to comprehensively assess infection, oxygenation, and wound analytics—A pilot study

Model-based quantitative assessment of skin microcirculatory blood flow and oxygen saturation

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