The construction and demolition waste generation rates (C&D WGRs) is an important factor in decision-making and management of material waste in any construction site. The present study investigated WGRs by conducting on-site waste sorting and weighing in four ongoing construction projects in Shenzhen city of South China. The results revealed that WGRs ranged from 3.275 to 8.791 kg/m(2) and miscellaneous waste, timber for formwork and falsework, and concrete were the three largest components amongst the generated waste. Based on the WGRs derived from the research, the paper also discussed the main causes of waste in the construction industry and attempted to connect waste generation with specific construction practices. It was recommended that measures mainly including performing waste sorting at source, employing skilful workers, uploading and storing materials properly, promoting waste management capacity, replacing current timber formwork with metal formwork and launching an incentive reward program to encourage waste reduction could be potential solutions to reducing current WGRs in Shenzhen. Although these results were derived from a relatively small sample and so cannot justifiably be generalized, they do however add to the body of knowledge that is currently available for understanding the status of the art of C&D waste management in China.

Construction sustainability performance is indispensable to the attainment of sustainable development. Various techniques and management skills have previously been developed to help improving sustainable performance from implementing construction projects. However, these techniques seem not being effectively implemented due to the fragmentation and poor coordination among various construction participants. There is a lack of consistency and holistic methods to help participants implementing sustainable construction practice at various stages of project realisation. This paper develops a framework of sustainability performance checklist to help understanding the major factors affecting a project sustainability performance across its life cycle. This framework enables all project parties to assess the project sustainability performance in a consistent and holistic way, thus improving the cooperation among all parties to attain satisfactory project sustainability performance.

Graphical Abstract Highlights d Single-cell transcriptome profiling constructs lncRNA landscape of HSC development d Computational and functional screening identifies 6 lncRNAs affecting hematopoiesis d Loss of H19 lncRNA results in failed HSC generation from endothelium in AGM region d H19 deficiency leads to promoter hypermethylation of Runx1 and Spi1 in pre-HSCs conceived and supervised the study; J.Z. and L.Z. performed the pre-HSC-and HSC-related experiments with help from J.H. and F.Z.; J.X. performed the bioinformatics analysis with help from X. Wen, Y.M., and Z.L.; S.L. performed shRNA construct and H19 mechanism study with help from Y.M., F.W., X. Wang, and Y.S.; X.L. performed single-cell RNAseq with support from F.T.; Q.L. performed DNA methylation sequencing with support from F.T.; Y.N. performed the flow cytometry with help from P.Z. and C.L.; M.B. provided H19-DMR flDMR/flDMR mice and edited the manuscript; and Y.L., J.Z., J.X., and Y.M. wrote the manuscript with help from J.Y. and B.L.

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