Chitinase OfChi-h, from the destructive
agricultural
pest Ostrinia furnacalis, is considered
as a promising target for green pest control and management. In this
study, structure-based virtual screening and rational molecular optimization
led to the synthesis of a series of azo-aminopyrimidine derivatives
as a novel class of OfChi-h inhibitors. Among them,
the most potent compound 8f, with a benzyl on the amino
group at the 4-position of pyrimidine, exhibited a K
i value of 64.7 nM against OfChi-h. In
addition, molecular docking studies were carried out to investigate
the basis for the potency of the aminopyrimidines against OfChi-h. Furthermore, the insecticidal activity of the target
compounds against Plutella xylostella and Ostrinia nubilalis was assessed,
and the potent OfChi-h inhibitors 8f and 8i showed higher insecticidal activity than the
control pesticide hexaflumuron. The present work revealed that the
azo-aminopyrimidine skeletons characterized by concise chemical structure
and high efficiency could be further developed as potential pesticides
for the control of lepidopteran pests.
Influencing factors for recovery of patients with gastrointestinal tumor after laparoscopic surgery were explored to promote recovery of patients. Clinical data from 521 gastrointestinal tumor patients who underwent laparoscopic surgery in Dalian Central Hospital were collected. The recovery of gastrointestinal function was recorded, and the factors that affected the recovery of gastrointestinal function were analyzed. All data were processed using Statistical Product and Service Solutions (SPSS) 21.0 software. t-test and F-test were used for univariate analysis, and multivariate linear regression was adopted for multivariate analysis. Results of univariate analysis displayed that age, starting time of postoperative activity, peritoneal drainage tube indwelling time, blood potassium level, sleep disorder, fasting and fluid deprivation time, duration of the first postoperative defecation/exhaustion, abdominal distention and pain reaction and social support level had significant influences on recovery of patients after operation (P<0.05). Results of multivariate analysis indicated that peritoneal drainage tube indwelling time, blood potassium level, fasting and fluid deprivation time and starting time of postoperative activity were independent factors affecting the recovery of patients after operation (P<0.05). Some methods are conducive to the recovery of gastrointestinal function in patients with gastrointestinal tumor, including the removal of peritoneal drainage tube, timely potassium supplementation, and diet recovery after laparoscopic surgery as soon as possible.
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