† Deceased. We dedicate this paper to Giorgio's memory. We will strive to make this experiment a great success and a tribute to his memory. He will be sorely missed. AbstractThe MoEDAL experiment at Point 8 of the LHC ring is the seventh and newest LHC experiment. It is dedicated to the search for highly ionizing particle avatars of physics beyond the Standard Model, extending significantly the discovery horizon of the LHC. A MoEDAL discovery would have revolutionary implications for our fundamental understanding of the Microcosm. MoEDAL is an unconventional and largely passive LHC detector comprised of the largest array of Nuclear Track Detector stacks ever deployed at an accelerator, surrounding the intersection region at Point 8 on the LHC ring. Another novel feature is the use of paramagnetic trapping volumes to capture both electrically and magnetically charged highly-ionizing particles predicted in new physics scenarios. It includes an array of TimePix pixel devices for monitoring highly-ionizing particle backgrounds. The main passive elements of the MoEDAL detector do not require a trigger system, electronic readout, or online computerized data acquisition. The aim of this paper is to give an overview of the MoEDAL physics reach, which is largely complementary to the programs of the large multi-purpose LHC detectors ATLAS and CMS. project grant; the V-P Research Notes 1 Defined to be a convolution of the efficiency and acceptance 2 The concept of Dirac (magnetic) charge is presented in Section 5. 3 If |n| = 1, this is only true for magnetic charge coupled to 2 H(S = 1, |q| = 1/2), 8 Li(S = 2, |q| = 3/2) and 10 B(S = 3, |q| = 5/2). 4 The reader should notice that the two-loop processes of Fig. 28(b), which couple the IC gluons to the fermionic SM sector suffer, in addition to the loop suppression, an additional helicity suppression, as compared to the diagram of Fig, 28(a), and are therefore non-leading contributions.

SummaryThe core functions of stem cells (SCs) are critically regulated by their cellular redox status. Glutathione is the most abundant non-protein thiol functioning as an antioxidant and a redox regulator. However, an investigation into the relationship between glutathione-mediated redox capacity and SC activities is hindered by lack of probe. Here, we demonstrate that cyanoacrylamide-based coumarin derivatives are ratiometric probes suitable for the real-time monitoring of glutathione levels in living SCs. These probes revealed that glutathione levels are heterogeneous among subcellular organelles and among individual cells and show dynamic changes and heterogeneity in repopulating SCs depending on oxidative stress or culture conditions. Importantly, a subpopulation of SCs with high glutathione levels exhibited increased stemness and migration activities in vitro and showed improved therapeutic efficiency in treating asthma. Our results indicate that high glutathione levels are required for maintaining SC functions, and monitoring glutathione dynamics and heterogeneity can advance our understanding of the cellular responses to oxidative stress.

We discuss how the surface gravity can be classically defined for dynamical black holes. In particular we focus on defining the surface gravity for locally defined horizons and compare a number definitions proposed in the literature. We illustrate the differences between the various proposals in the case of an arbitrary dynamical, spherically symmetric black hole spacetime. We also discuss how the trapping horizon formalism of Hayward can be related to other constructions.

MoEDAL is designed to identify new physics in the form of long-lived highly ionizing particles produced in high-energy LHC collisions. Its arrays of plastic nuclear-track detectors and aluminium trapping volumes provide two independent passive detection techniques. We present here the results of a first search for magnetic monopole production in 13 TeV proton-proton collisions using the trapping technique, extending a previous publication with 8 TeV data during LHC Run 1. A total of 222 kg of MoEDAL trapping detector samples was exposed in the forward region and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges exceeding half the Dirac charge are excluded in all samples and limits are placed for the first time on the production of magnetic monopoles in 13 TeV pp collisions. The search probes mass ranges previously inaccessible to collider experiments for up to five times the Dirac charge.

Abstract:The MoEDAL experiment is designed to search for magnetic monopoles and other highly-ionising particles produced in high-energy collisions at the LHC. The largely passive MoEDAL detector, deployed at Interaction Point 8 on the LHC ring, relies on two dedicated direct detection techniques. The first technique is based on stacks of nucleartrack detectors with surface area ∼18 m 2 , sensitive to particle ionisation exceeding a high threshold. These detectors are analysed offline by optical scanning microscopes. The second technique is based on the trapping of charged particles in an array of roughly 800 kg of aluminium samples. These samples are monitored offline for the presence of trapped magnetic charge at a remote superconducting magnetometer facility. We present here the results of a search for magnetic monopoles using a 160 kg prototype MoEDAL trapping detector exposed to 8 TeV proton-proton collisions at the LHC, for an integrated luminosity of 0.75 fb −1 . No magnetic charge exceeding 0.5g D (where g D is the Dirac magnetic charge) is measured in any of the exposed samples, allowing limits to be placed on monopole production in the mass range 100 GeV≤ m ≤ 3500 GeV. Model-independent cross-section limits are presented in fiducial regions of monopole energy and direction for 1g D ≤ |g| ≤ 6g D , and model-dependent cross-section limits are obtained for Drell-Yan pair production of spin-1/2 and spin-0 monopoles for 1g D ≤ |g| ≤ 4g D . Under the assumption of Drell-Yan cross sections, mass limits are derived for |g| = 2g D and |g| = 3g D for the first time at the LHC, surpassing the results from previous collider experiments.

We update our previous search for trapped magnetic monopoles in LHC Run 2 using nearly six times more integrated luminosity and including additional models for the interpretation of the data. The MoEDAL forward trapping detector, comprising 222 kg of aluminium samples, was exposed to 2.11 fb −1 of 13 TeV proton-proton collisions near the LHCb interaction point and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to the Dirac charge or above are excluded in all samples. The results are interpreted in Drell-Yan production models for monopoles with spins 0, 1/2 and 1: in addition to arXiv:1712.09849v4 [hep-ex]

The latest MoEDAL experiment at LHC to detect the electroweak monopole makes the theoretical prediction of the monopole mass an urgent issue. We discuss three different ways to estimate the mass of the electroweak monopole. We first present the dimensional and scaling arguments which indicate the monopole mass to be around 4 to 10 TeV . To justify this we construct finite energy analytic dyon solutions which could be viewed as the regularized Cho-Maison dyon, modifying the coupling strength at short distance. Our result demonstrates that a genuine electroweak monopole whose mass scale is much smaller than the grand unification scale can exist, which can actually be detected at the present LHC.

No abstract