MoEDAL is designed to identify new physics in the form of long-lived highly ionizing particles produced in high-energy LHC collisions. Its arrays of plastic nuclear-track detectors and aluminium trapping volumes provide two independent passive detection techniques. We present here the results of a first search for magnetic monopole production in 13 TeV proton-proton collisions using the trapping technique, extending a previous publication with 8 TeV data during LHC Run 1. A total of 222 kg of MoEDAL trapping detector samples was exposed in the forward region and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges exceeding half the Dirac charge are excluded in all samples and limits are placed for the first time on the production of magnetic monopoles in 13 TeV pp collisions. The search probes mass ranges previously inaccessible to collider experiments for up to five times the Dirac charge.

We update our previous search for trapped magnetic monopoles in LHC Run 2 using nearly six times more integrated luminosity and including additional models for the interpretation of the data. The MoEDAL forward trapping detector, comprising 222 kg of aluminium samples, was exposed to 2.11 fb −1 of 13 TeV proton-proton collisions near the LHCb interaction point and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to the Dirac charge or above are excluded in all samples. The results are interpreted in Drell-Yan production models for monopoles with spins 0, 1/2 and 1: in addition to arXiv:1712.09849v4 [hep-ex]

In this work we consider point-like monopole production via photon-fusion and Drell–Yan processes in the framework of an effective U (1) gauge field theory obtained from conventional models describing the interaction of spin magnetically-charged fields with ordinary photons, upon electric-magnetic dualisation . We present arguments based on such dualities which support the conjecture of an effective monopole-velocity-dependent magnetic charge. For the cases of spin- and spin-1 monopoles, we also include a magnetic-moment term , which is treated as a new phenomenological parameter and, together with the velocity-dependent coupling, allows for a perturbative treatment of the cross-section calculation. We discuss unitarity issues within these effective field theories, in particular we point out that in the spin-1 monopole case only the value may restore unitarity. However from an effective-field-theory point of view, this lack of unitarity should not be viewed as an impediment for the phenomenological studies and experimental searches of generic spin-1 monopoles, given that the potential appearance of new degrees of freedom in the ultraviolet completion of such models might restore it. The second part of the paper deals with an appropriate implementation of photon-fusion and Drell–Yan processes based on the above theoretical scenarios into MadGraph UFO models, aimed to serve as a useful tool in interpretations of monopole searches at colliders such as LHC, especially for photon fusion, given that it has not been considered by experimental collaborations so far. Moreover, the experimental implications of such perturbatively reliable monopole searches have been laid out.

Deoxyfuconojirimycin (1,5-dideoxy-1,5-imino-L-fucitol) is a potent, specific and competitive inhibitor (Ki 1 x 10(-8) M) of human liver alpha-L-fucosidase (EC 3.2.1.51). Six structural analogues of this compound were synthesized and tested for their ability to inhibit alpha-L-fucosidase and other human liver glycosidases. It is concluded that the minimum structural requirement for inhibition of alpha-L-fucosidase is the correct configuration of the hydroxy groups at the piperidine ring carbon atoms 2, 3 and 4. Different substituents in either configuration at carbon atom 1 (i.e. 1 alpha- and beta-homofuconojirimycins) and at carbon atom 5 may alter the potency but do not destroy the inhibition of alpha-L-fucosidase. The pH-dependency of the inhibition by these amino sugars suggests very strongly that inhibition results from the formation of an ion-pair between the protonated inhibitor and a carboxylate group in the active site of the enzyme. Deoxymannojirimycin (1,5-dideoxy-1,5-imino-D-mannitol) is also a more potent inhibitor of alpha-L-fucosidase than of alpha-D-mannosidase. This can be explained by viewing deoxymannojirimycin as beta-L-homofuconojirimycin lacking the 5-methyl group. Conversely, beta-L-homo analogues of fuconojirimycin can also be regarded as derivatives of deoxymannojirimycin. This has permitted deductions to be made about the structural requirements of inhibitors of alpha- and beta-D-mannosidases.

MoEDAL is designed to identify new physics in the form of stable or pseudostable highly ionizing particles produced in high-energy Large Hadron Collider (LHC) collisions. Here we update our previous search for magnetic monopoles in Run 2 using the full trapping detector with almost four times more material and almost twice more integrated luminosity. For the first time at the LHC, the data were interpreted in terms of photon-fusion monopole direct production in addition to the Drell-Yan-like mechanism. The MoEDAL trapping detector, consisting of 794 kg of aluminum samples installed in the forward and lateral regions, was exposed to 4.0 fb −1 of 13 TeV proton-proton collisions at the LHCb interaction point and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to or above the Dirac charge are excluded in all samples. Monopole spins 0, 1 /2 and 1 are considered and both velocity-independent and -dependent couplings are assumed. This search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge.

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We present explicit examples of supergravity solutions corresponding to backreacting localised (non-intersecting) O6 planes in flux reductions of massive IIA supergravity and address some criticism towards the very existence of such solutions. We verify in detail how the smeared orientifold solution becomes a good approximation to the localised solution in the large volume/weak coupling limit, as expected. We also find an exotic solution where prior to backreaction the internal space has a boundary and when backreaction is included the boundary disappears and the space closes off. The exotic example is however outside of the supergravity approximation everywhere.