Celiac disease (CD) is chronic inflammatory disease of the proximal small intestine. It is caused by hypersensitivity to gluten proteins, rays and barley, which damage the intestinal mucous membrane, creating conditions for malabsorption. In addition to intestinal, classic forms of the disease, extraintestinal manifestations may occur. Aphthae in the oral cavity, defects of the enamel, caries, delayed tooth erupting, atrophic glossitis and angular cheilitis are some of them. Serological examination of patients with minimal symptoms and in patients with extraintestinal and atypical gastrointestinal symptoms would improve the timely diagnosis. By careful dental examination of the cavity with a special focus on these changes, we can contribute to early diagnosis of the CD. The education of patients about oral manifestations of CD can improve the quality of life of these patients.
Rotavirus is the most common cause of acute infectious diarrhea in infants and young children up to the age of five. The disease is characterized by profuse watery diarrhea, vomiting and fever. The major complications of rotavirus gastroenteritis (RVGE) are dehydration, middle ear inflammation and upper respiratory tract infection. The basis of treatment is compensation for fluid loss and administration of probiotics. The aim of this study was to analyze the clinical characteristics of rotavirus gastroenteritis in infants. The study was conducted by the type of retrospective-prospective clinical study on infants with rotavirus gastroenteritis diagnosed on the basis of a positive Rotalex test (Orion Diagnostica Finland) and exclusion of other etiological factors at the University Children’s Clinic in Belgrade, from April 2005 to December 2010. In addition to the detailed medical history and clinical examination, relevant laboratory analyzes were performed in all patients. Descriptive and analytical statistical methods were applied in the study. Among the descriptive methods, we used grouping, tabulation, graphing, calculating measures of central tendency, calculating measures of variability and calculating relative numbers. Of the analytical statistical methods, distribution normality testing, χ2 test, Mann-Whitney U test and T test were used. Statistical significance will be taken to mean p < 0.05. The average infant mortality was 6.7 ± 3.7 months. All respondents were divided into two groups according to the age. The first group consisted of infants aged 0 to 5 months (46%), the second group consisted of infants aged 6 to 12 months (54%). The incidence of aqueous diarrhea (100%), vomiting (84%) and fever (74%) in infants suffering from rotavirus gastroenteritis was analyzed. The significance of the age on the symptomatology of rotavirus gastroenteritis as well as on the importance of using probiotics has been demonstrated.
УводИнфламацијске болести црева (IBD), као идиопатски, хронични поремећaји са имуногенетеском основом, често су удружени са екстраинтестиналним манифестацијама (ЕIМs). Екстраинтестиналне манифестације Кронове болести (CD) и улцерозног колитиса уочене су код око 35% оболелих од инфламацијских болести црева. Понекад утичу на укупни квалитет живота много више од симптома који прате болести црева.Екстраинтестиналне манифестације треба разликовати од секундарних обољења или компликација инфламацијских болести црева, јер захтевају евентуално другачији приступ и специфичну терапију. Скоро сваки орган може бити локализација екстраинтестиналних симптома инфламацијских болести црева (1). Понекад представљају примарне манифестације Кронове болести и улцерозног колитиса. Најчешће су захваћени зглобови, кожа, очи, али могу бити захваћени и други органи, као што су јетра и жучни путеви, урогенитални систем и хематопоезни систем.ЕIМs могу бити подељене у две групе: реактивне манифестације које су у вези са активношћу болести, као што су периферни артритис, еритема нодозум PREGLEDNI ČLANAK СажетакЕкстраинтестиналне манифестације Кронове болести и улцерозног колитиса уочене су код скоро половине оболелих. Треба их разликовати од секундарних обољења и компликација. Најчешће захваћени органи jeсу зглобови, кожа, очи, ређе јетра, жучни путеви, урогенитални и хематопоезни систем. Манифестације на оку су, иако ретке, значајан вид морбидитета, са могућим слепилом као исходом. Преваленција је већа код жена и када су болести црева дијагностиковане у ранијој животној доби, а мања је код деце. Узимајући у обзир велики утицај на квалитет живота, неретко и више од гастроинтестиналних симптома, циљ рада је да укаже на учесталост и важност препознавања, размотри клинички и дијагностички приступ појединим офталмолошким ентитетима. Симптоматологија промена на оку, најчешће иритиса, еписклеритиса и склеритиса није специфична, те је самим тим и клиничка евалуација потенцијално потцењена како из угла пацијента, тако и из угла лекара. Офталмолошки преглед би требало да буде учесталија процедура и саставни део неге пацијената са инфламацијским болестима црева. Неопходно је бити добро упознат са могућим симптомима на оку, јер у појединим случајевима они претходе инфламацијским болестима црева. Лечење и адекватна контрола основне системске болести у највећој мери доприносе контроли болести ока.Кључне речи: инфламацијске болести црева, увеитис, склеритис. AbstrActExtraintestinal manifestations of Crohn's disease and ulcerative colitis were observed in almost half of the patients. They should be distinguished from secondary illnesses and complications. The most commonly affected organs are joints, skin, eyes, liver, gallbladder, urogenital and hematopoietic system. Eye manifestations are, although rare, an important form of morbidity, with possible blindness. The prevalence is higher in women and if the bowel disease is diagnosed at younger age, but lower than in children. Considering the great impact on the life quality, sometimes higher than gastrointe...
Introduction. Despite the high incidence of hemorrhoidal disease and the widespread use of numerous topical preparations, there is still a lack of information regarding their efficacy. Therefore, the aim of this study was to assess the efficacy and tolerability of a new topical medical preparation containing sodium hyaluronate, calendula extract, hamamelis extract and mentha piperita essential oil as major components. Material and Methods. This prospective double-blind randomized clinical study included 49 patients with a diagnosis of hemorrhoidal disease. The patients were randomly assigned to two groups: Avaricon ® group that included patients who applied 0.20% Avaricon ® Hemor and a placebo group who applied placebo during 2 weeks. The effects of Avaricon ® Hemor on the symptoms of hemorrhoidal disease, its safety, tolerability as well as compliance and adherence of study patients were analyzed. Results. Our results showed that Avaricon ® Hemor was significantly superior to placebo in controlling most symptoms of hemorrhoidal disease. Conclusion. The tested medical agent showed to be effective with good tolerability and safety profile indicating its possible use in various therapeutic protocols in the management of hemorrhoidal disease.
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