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INTRODUCTION:Advanced platelet-rich fibrin (A-PRF) is one of the most recently developed platelet concentrates and believed to have a great impact in regeneration for its richness in leukocytes, platelets, stem cells and cytokines. Biphasic calcium phosphate (BCP) alloplast is a well-known synthetic bone substitute widely used in periodontal regeneration. OBJECTIVES: To evaluate the additive effect of A-PRF to BCP in regeneration of intrabony defects. MATERIALS AND METHODS: Twenty two interproximal, intrabony defects in 22 patients with moderate to severe chronic periodontitis were allocated to one of the two groups of this study. Group I (test) was treated with open flap debridement followed by placing A-PRF and BCP with a ratio of 1:1, while group II (control) was filled only by BCP mixed with saline after open flap debridement (OFD). Plaque index (PI), modified gingival index (MGI), probing depth (PD) and clinical attachment level (CAL) were evaluated at baseline, 3, 6 and 9 months. RESULTS: Compared to baseline all evaluated parameters showed improvement at the end of the study in both groups. Changes from baseline to 9 months in A-PRF/BCP group were insignificantly greater compared to BCP/saline group regarding reduction of PI (0.54±0.72 vs 0.53±0.92), MGI (0.34±0.68 vs 0.32±0.78), PD (2.27±0.71mm vs 2.04±0.96mm) and CAL gain (2.13±1.02mm vs 1.68±1.23mm). However, intergroup differences were insignificant. CONCLUSIONS: Based on results of this study, combining advanced platelet-rich fibrin to biphasic alloplast mixture was more advantageous than using BCP alone in intrabony defect management.

Background: Oral lichen planus is one of the most prevalent oral diseases. Matrix metalloproteinases have been implicated in its pathogenesis thus this study was executed to evaluate the effectiveness of matrix metalloproteinases neutralizing agents in the treatment of oral lichen planus. Methods: Patients were assigned to either control group who received topical corticosteroids and antifungal treatment, or test group who received matrix metalloproteinases neutralizing spray. All patients were evaluated for disease severity and pain at baseline, 1 week, and 4 weeks after treatment. Results: The mean pain score in test and control groups was 9.00 (0.89), and 9.33 (0.82), respectively, at baseline while it was 2.33 (1.75) and 2.83 (1.72) at 4th week follow up. The mean disease severity score was 4.33 (0.52) for test group and 4.50 (0.55) for control group at baseline and decreased to 1.83 (0.75) and 2.17 (0.98) at 4th week follow up. Despite the better results seen in test group on the expense of control group, no statistically significant differences could be detected between groups at any timepoint. Conclusion: The use of matrix metalloproteinases neutralizing agents might be an equally effective sole treatment for erosive oral lichen planus compared to the conventional treatment, without the risk of secondary candidiasis. Trial registration: The study was registered retrospectively at ClinicalTrials.gov (NCT04336488), date (07/04/2020)