A novel, rapid and simple reverse-phase high performance liquid chromatography (RP-HPLC) method for the simultaneous determination of three pesticides – mancozeb, azoxystrobin and difenoconazole by derivatization with ethyl iodide is presented.
Simple, cost-effective method for synthesis of 4,5dihydro-1H-pyrazole derivatives from 1,3-diphenyl -2-propen-1ones and phenyl hydrazine employing "nonconventional" deep eutectic solvent (DES) as "green" reaction media and catalyst, has been completed effectively. We optimize this cyclisation by using different greener solvents and we got surprising results from Choline chloride:glycerol (1:2) as a DES. Hydrogen-bond donating characteristics and high dissolution property increases the yield of pyrazoline derivatives. DES avoids the use of toxic catalyst and volatile solvents. Structures of the synthesized compounds have been elucidated by means of IR, 1H NMR and mass spectral data. The antibacterial activity of the synthesized compounds was performed by Agar well diffusion method.
Objectives:
The synthesis of 4-((1-phenyl-3-(substitutedphenyl)-1H-pyrazol-4-yl) methylene)-4H-pyrazol-3,5-diamine and 3-amino-4-((1-phenyl-3-(substitutedphenyl)-1H-pyrazol-4-yl) methylene)-1H-pyrazol-5(4H)-one was designed and performed very aptly in deep eutectic solvent system.
Methods:
The utilization of deep eutectic solvent (DES) system ChCl/Gly (1:2) in absence of hazardous organic co-solvents, an efficient multicomponent one-pot synthetic strategy has been advanced. In addition to that, from the perspectives of sustainable developments in organic synthesis the deep eutectic solvent system was recovered and very efficiently reused up to four cycles.
Results:
It has been observed that the efficacy of the deep eutectic solvent was decreased after the second cycle, which has a measurable impact on the yield of the reaction.
Conclusion:
Furthermore, the synthesized aminopyrazole and aminopyrazolone compounds were screened as antibacterial and antifungal agents.
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