Objectives: This study aimed to externally validate the diagnostic accuracy of the Select MDx test for Significant prostate cancer (Sig PCa) (ISUP > 1), in a contemporaneous, prospective, multicenter cohort with a prostate-specific antigen (PSA) between 3 and 10 ng/ml and a non-suspicious digital rectal examination.Methods and Participants: For all enrolled patients, the Select Mdx test, the risk calculator ERSPC3 + DRE, and a prostatic magnetic resonance imaging (MRI) were carried out. Subsequently, a systematic 12-core trans-rectal biopsy and a targeted biopsy, in the case of a prostate imaging-reporting and data system (PIRADS) > 2 lesion (max three lesions), were performed. To assess the accuracy of the Select MDx test in the detection of clinically Sig PCa, the test sensitivity was evaluated.Secondary objectives were specificity, negative predictive value (NPV), positive predictive value (PPV), and area under the curve (AUC). A direct comparison with the ERSPC + DRE risk calculator and MRI were also performed. We also studied the predictive ability to diagnose Sig PCa from the combination of the Select MDx test with MRI using clinical decision-curve analysis.Results: There were 163 patients enrolled after meeting the inclusion criteria and study protocol. The Select MDx test showed a sensitivity of 76.9% (95% CI, 63.2-87.5), 49.6% specificity (95% CI, 39.9-59.2), 82.09% (95% CI, 70.8-90.4) NPV, and 41.67% (95% CI, 31.7-52.2) PPV for the diagnosis of Sig PCa. COR analysis was also performed, which showed an AUC of 0.63 (95% CI, 0.56-0.71). There were no differences in the accuracy of Select MDx, ERSPC + DRE, or MRI. The combination
This work analyses the denotative and connotative visual framing of migrants and refugees in European media during the migration crisis in Europe in general and in the Mediterranean in particular. The main objective is to identify the differences between Germany, the country that receives the most asylum requests, and other Western Europe countries (Spain, France, Italy and the United Kingdom). The second goal is to detect temporal differences between the first period of the crisis (2013-2014) and the second period (2015-2017), when the conflict worsened. We content analysed a sample of 500 news photographs from 10 media outlets of five European countries. The results indicate that the most predominant visual frame represents migrants and refugees as victims. However, it was also observed that the frames depicting these individuals as a threat to Western societies are more frequent in German media, and also during the second period of the crisis.
The Mediterranean migration crisis especially affects three Southern European countries that represent the main gateways into the continent for immigrants and asylum seekers: Spain, Italy, and Greece. In recent years, feelings of rejection towards migration have been increasing in all of them, accompanied by a simultaneous increase in the number of hate crimes. Similarly, the representation of these groups in European news media seems to have worsened, especially since 2015, the year in which the migratory crisis significantly worsened. This coverage could be affecting European citizens on emotional, cognitive, and attitudinal levels and thus should be rigorously analyzed. The present study is based on the theory of framing and, specifically, on visual framing to analyze the connotative representations of immigrants and refugees spread by the reference media of Southern Europe through images, paying more attention to the negative frames in particular, which represent displaced people as a burden or threat. Specifically, 360 photographs taken between 2014 and 2019 and published by the main media in Spain, Italy, and Greece were subject to content analysis. The findings show a temporal increase in the negative visual frames of immigrants and refugees in the analyzed media. Differences were also found between countries, with Greece presenting a higher percentage of images with negative frames, as well as a greater predominance of this type of frame compared with the other countries. Finally, differences were identified between the media themselves, including the Greek Kathimerini, a media outlet that stands out for the amount and prevalence of photographs framing immigrants and asylum seekers as a burden and threat. Resumen La crisis migratoria del Mediterráneo afecta especialmente a tres países del sur de Europa, que son la principal puerta de entrada de inmigrantes y solicitantes de asilo en el continente. Estos países son España, Italia y Grecia, y en todos ellos los sentimientos de rechazo a la migración han ido en aumento en los últimos años, acompañados por el incremento simultáneo de los delitos de odio. De igual forma, la representación de estos grupos en los medios informativos europeos parece haber empeorado, especialmente a partir de 2015, año en el que la crisis migratoria se agravó mucho. Esta cobertura podría estar afectando a las actitudes de los ciudadanos europeos hacia los desplazados, por lo que conviene analizarla de manera rigurosa. El presente estudio se basa en la teoría del encuadre y, en específico, en el visual framing para analizar los marcos connotativos de inmigrantes y refugiados que transmiten los medios de referencia del sur de Europa a través de sus imágenes durante la crisis migratoria, prestando una mayor atención a los marcos negativos, los que representan a estas personas como una carga o amenaza. Así, a través de un análisis de contenido se examinaron 360 fotografías publicadas por los principales medios de España, Italia y Grecia entre 2014 y 2019. Los resultados muestran un incremento temporal de los marcos visuales negativos de inmigrantes y refugiados en los medios analizados. También se encontraron diferencias entre países, presentando Grecia un mayor porcentaje de imágenes con marcos negativos, así como una mayor predominancia de los marcos negativos que el resto de países. Por último, se identificaron diferencias entre los propios medios, siendo el griego Kathimerini el que destaca por tener una mayor presencia de imágenes con marcos de carga y de amenaza, y una mayor predominancia de estos marcos en sus fotografías.
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