The hematologic findings in 22 cases of mammary cancer metastatic to bone marrow are presented. Cancer of the breast was the most frequent neoplasm metastatic in bone marrow in this study of 2,878 bone-marrow examinations. All 22 patients who had carcinoma of the breast metastatic to bone marrow had clinical, radiographic, or hematologic evidence of widespread metastatic disease. Peripheral blood was abnormal in 58% of the cases, and in most of these cases two or more abnormalities were present. Bone-marrow biopsies were superior to particle sections and aspirates in identifying tumor, but correlations among all modalities were necessary for proper interpretation. Although the morphologic features of tumor cells in sections and smears were quite characteristic for carcinoma of the breast, pitfalls in interpretation were numerous and should be recognized. The mean survival time of these patients was only 6.9 months after identification of bone-marrow metastases. The significant response to chemotherapy obtained with some individuals, however, should encourage aggressive therapy of this disorder.
Spectrometers that include extended-range linear InGaAs arrays make it possible to measure optical signals to 2500 nm. Available arrays, however, have more than 100 times the dark current as that of conventional arrays, which are limited to 1700 nm. This behavior leads to non-linearity in a short-wave infrared spectroradiometer used to monitor spectral radiance of an integrating sphere uniform source. A method of improving linearity in an extended-range InGaAs array is presented. The non-linearity is corrected using a multi-point calibration at a number of lamp power levels whereby the calibration factor for each wavelength point depends on the lamp power in the integrating sphere. An algorithm in the spectroradiometer software chooses the correct calibration factors and reports the system spectral radiance values accordingly. This method reduced error by more than a factor of two.
LCD backlighting applications require diffuse illumination over an extended area of a display unit while maintaining high luminance levels. Since such applications involve multiple reflections within a reflective cavity, the efficiency of the cavity can be affected significantly by relatively small changes in the reflectance of the cavity material. Materials with diffuse rather than specular (or mirror-like) reflectance scatter light, averaging out hot spots and providing a uniform field of illumination. Reflectors with specular components tend to propagate non-uniformities in the illuminator system. The result is a spatial variation in brightness visible to the viewer of the display. While the undesirability of specular materials for such applications has been widely recognized, some diffuse materials in common use exhibit a significant specular component. This paper describes a method for measuring the specular component of such materials, and presents a simple approach to evaluating the effect of such secondary specular behavior on the performance of a backlight cavity. It is demonstrated that significant differences exist among available diffuse reflectance materials, and that these differences can lead to significant differences in the performance of the displays in which these materials are used.
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