(1) Purpose: In this article, the authors decided to systematically review the available literature to identify potential correlations regarding secondary oral carcinoma occurring after hematological systemic treatment and oral chronic graft-versus-host disease. (2) Methods: Medline (PubMed) and Scopus (Elsevier) databases were searched, including articles from the years 2002–2022. The 33 unique results were assessed by a PRISMA flowchart, and we rejected 24 papers and included 9 articles in the review. (3) Results: The majority of patients suffered from the oral form of chronic graft-versus-host disease before the diagnosis of oral malignancy. Two common cancer sites were the tongue and buccal mucosa. The exact percentage of secondary oral carcinoma after hematopoietic stem cell transplantation could not be estimated due to a lack of data. (4) Conclusions: Every physician taking part in the follow-up of patients after hematological treatment should be aware of the possibility of secondary neoplastic disease in the oral cavity, especially in patients with oral graft-versus-host disease. Proper follow-up protocols and monitoring are needed in this patient group as the cause of these cancers appears to be multifactorial.
Bruton's tyrosine kinase (BTK) is a part of the B-cell receptor (BCR) signaling pathway.Activation of the BCR appears crucial for normal B cells as it regulates proliferation, differentiation, adhesion, survival, and apoptosis. Such signaling is also vital for malignant B cells, since many of them show constitutive activation of the BCR pathway. The development of ibrutinib, a best-in-class BTK inhibitor, has led to a new direction in the treatment of B-cell malignancies. Further studies have enabled the development of more potent and more selective BTK inhibitors, such as zanubrutinib. These novel agents were designed primarily to reduce adverse effects such as diarrhea, atrial fibrillation, rash, or hemorrhagic complications.Compelling data from clinical studies that have verified its efficacy and safety has allowed the approval of zanubrutinib in hematological malignancies such as mantle cell lymphoma, Waldenström's macroglobulinemia, chronic lymphocytic leukemia, and marginal zone lymphoma.
Based on the analysis of surgical instruments withdrawn from the operating theatre, it was decided to briefly present the history of osteosynthesis in the orthopaedic department in Gdansk, Poland. Boxes with orthopaedic instruments withdrawn from the operating theatre were obtained. The instruments were grouped, numbered, photographed and catalogued. Not all obtained instruments were used in orthopaedics; the boxes contained several instruments typically used in other fields of surgery. Attempts have been made to divide orthopaedic instruments into several groups, depending on their use in bone fixation. Some specific instruments are used only in one method. The most interesting tools are discussed in detail, with attention to their features and role in shaping modern orthopaedics. Some of the obtained equipment could have been made in the Orthopaedic Workshop in the hospital. They are specific exhibits related to the development of orthopaedics in this hospital that required preservation.
Objectives: Hemoptysis in pregnancy is a very rare finding causing diagnostic and therapeutic difficulties. The case report of hemoptysis by a 29 years old patient in the 31st week of pregnancy is presented and discussed along with the diagnostic process and treatment provided. Upon pharyngeal cancer occurrence in a pregnant patient a multidisciplinary medical team performed appropriate treatment along with delivery of a healthy newborn at term. Patients and fetal conditions and outcomes were analyzed and compared to available literature in this newly created literature review.
Material and methods:After MEDLINE database analysis using formula "hemoptysis" AND "pregnancy" more than 125 results were found published during the period 2002-2022.Almost 30 papers about hemoptysis were found and included for full analysis.
Conclusions:The literature review offers a detailed description of previously reported incidents of hemoptysis in pregnancy to gain understanding of the etiology, differential diagnosis, available treatment and predicted future outcomes for both patient and fetus.
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