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Objective: Studies on odontogenic tumors published from many parts of the world show a distinct geographic variation; however, there is little information available in the English-language literature on the relative frequency of odontogenic tumors in India. This retrospective study was designed to determine the relative frequency of odontogenic tumors in an Indian population and compare them with various reports from other parts of the world. Study design: The histopathology records of the Department of Oral Pathology and Microbiology of Government Dental College and Hospital, Mumbai were retrieved retrospectively within the period of January 2001 to July 2010. A total of 120 lesions classified as odontogenic tumors were reviewed. These were analyzed for age, gender, site of tumor and histopathologic typing. Criteria used were World Health Organization (WHO) classification 2005. The mandible and maxilla were divided into 4 anatomic regions, and the distribution of each odontogenic tumor among these regions was recorded and analyzed. Results: A total of 120 cases of odontogenic tumors were reported in this period. Odontogenic tumors in the present study constituted 5.78% of all the 2075 registered biopsies. The most frequent histological type was ameloblastoma (40.83%), followed by Keratocystic odontogenic tumor (37.5%), odontome (11.66%) and adenomatoid odontogenic tumor (5.8%). In general, the odontogenic tumors showed a predilection for the mandible and the posterior regions of the jaws. Ameloblastomas occurred with a marked predilection for the mandible, while adenomatoid odontogenic tumor showed predilection for the maxilla, anterior regions of the jaws, and young females. Conclusion: A frequency of 5.78% of odontogenic tumors was observed in this study. Ameloblastoma comprised the single most common tumor of all odontogenic tumors. This study observed geographic variations in the frequency and distribution of odontogenic tumors.

Dentinogenic ghost cell tumor (DGCT) is a rare, odontogenic neoplasm which is considered to be a solid variant of calcifying odontogenic cyst (COC) with locally aggressive behavior. It accounts for only 2–14% of all COCs. To the best of our knowledge, only 88 cases of DGCT have been reported in the literature from 1968 to 2014. Herewith, we report a case of DGCT in a 68-year-old male patient with clinical presentation as a soft tissue growth over alveolar ridge and histopathologically characterized by ameloblastomatous epithelium, abundance of eosinophilic material and ghost cells.

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Several attempts to produce internationally accepted terminologies and definitions of ‘oral precancer’ have appeared in the literature. World Health Organizations (WHO) in 1972 subdivided ‘precancer’ into ‘lesions’ and ‘conditions’ with their definitions. Recent working group of WHO is not in favor of such subdivision and recommended the use of the term ‘oral potentially malignant disorder (OPMD)’. This is mainly attributed to the recent advancement in molecular and genetic aspects of ‘oral precancer’. But efforts to define OPMDs are few in the literature. ‘Oral precancer’ is ultimately colligated to oral squamous cell carcinoma (OSCC). With this semantics in mind, different OPMD and related terminologies in the literature used till date with their lexicographic analysis have been reviewed in the present paper. Attempt has also been made to propose desirable terminology and definition which suits to the current concept of OPMD. The proposed terminology and definition is based on the authors’ opinions with a hope for further suggestions from readers.

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Amaç: E-cadherin'in displazinin kansere dönüşmesinde rol oynayabileceğine dair bulgular vardır. Bu çalışmanın amacı E-cadherin'in ağız içi normal mukoza, yassı epitel hücreli karsinom ve displastik epitelde ekspresyonunu karşılaştırarak oral karsinogenez ile ilişkisini araştırmaktır. Gereç ve yöntem: Klinik olarak oral premalin lezyon ve yassı epitel karsinom şüphesi bulunan hastalar, histopatolojik tanıyı takiben çalışmaya alındı. Toplam olarak oral epitelyal displazili 20 hasta ve oral yassı epitel hücreli karsinomu bulunan 20 hasta çalışmaya alındı. Her hastada aşağıdaki değişkenler kaydedildi: Hastanın yaşı, cinsiyeti, tümör lokalizasyonu, TNM evresi ve klinik evre (I-IV). Hematoksilen-Eozin'le boyanmış kesitlerin ilk muayenesini takiben, her parçadan bir kısım alınarak 5 mikronluk kesitler halinde immunohistokimyasal çalışmaya alındı. Bulgular: E-cadherin ekspresyonu ile displazi arasında negatif bir bağlantıyı telkin eder tarzda, hafiften ağıra değişen derecedeki displazide E-cadherin ekspresyonu azalmış bulundu. Ayrıca E-cadherin ekspresyonu ile klinik tümör evresi ve prognoz skoru arasında anlamlı bir bağıntı saptanmadı. Sonuç: Oral yassı hücreli karsinomda displazi derecesi arttıkça E-cadherin ekspresyonu azalmaktadır. Azalmış E-cadherin ekspresyonu ağız içi yassı epitel hücreli karsinoma'da invazivlikte artışın güvenilir bir belirteci olabilir. Azalmış E-cadherin ekspresyonu displazini oral kansere dönüşmesini gösteren faydalı bir belirteç olarak düşünülebilir. Anahtar kelimeler: E-cadherin, oral epitelyal displazi, oral yassı epitel hücreli karsinoma ABSTRACT Objectives: There is evidence that E-cadherins may also play a role in progression of dysplasia to cancer. The aim of this study was to investigate the expression of E-cadherin during the process of oral carcinogenesis by comparing their expression in normal and oral dysplastic epithelium (OED) with oral squamous cell carcinoma (OSSC). Materials and methods: The patients who were clinical suspected of having premalignant lesion and oral squamous cell carcinoma were included in the study after the histopathological diagnosis. Totally 20 cases of OED and 20 Cases of OSSC were included in the study. From each case the following data were recorded: patient's age and sex, tumour location, TNM classification and clinical stage (I-IV). After preliminary examination of sections stained with haematoxylin/eosin, representative parts of each piece were selected and sectioned at 5 micron for immunohistochemical study. Results: There was reduced expression of E-cadherin from mild to severe degree of dysplasia suggesting the negative correlation with E-cadherin expression. However, there was no significant correlation between E-cadherin expression, clinical TNM stage and prognosis score. Conclusion: The E-cadherin expression is reduced with increase grade of dysplasia and in oral squamous cell carcinoma. The reduced expression of E-cadherin may be a reliable indicator of increase in invasiveness in oral squamous cell carcinoma. Reduced E-cadherin expression can...