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Plasma fibrinolytic activity, as measured by the fibrin-plate method, is enhanced after an intravenous injection of 40 mg furosemide. The effect is evident within 30 minutes of the injection and attains a peak after 6 hours. If a second injection of furosemide is given at this stage, the increased fibrinolytic activity persists, and a slightly higher peak than the first is obtained again 6 hours after this injection. After the furosemide injection, there is an initial decrease of urokinase excretion which returns to normal after 3 to 6 hours.The decrease of urokinase excretion is attributed to a dilution effect during increased diuresis and the rise in fibrinolytic activity by furosemide is attributed to its vasodilatory activity and cyclic-AMP phosphodiesterase inhibitory capacity. It also appears related to the Hageman factor dependent pathway of fibrinolysis. In the treatment of high altitude pulmonary oedema, furosemide restores factor XII and fibrinolytic activity, which are both depressed in this disease (I. Singh and I.S. Chohan, Int. J. Biometeor. 18, 33, 1974).

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SummaryThe lytic activity was measured in blood obtained from a superficial elbow vein when a cuff with a known pressure was attached above the elbow and compared with the activity in the blood taken at the same moment from the control arm without any pressure.1. Using a pressure 20 mm above the systolic pressure, no enhancement could be obtained in the first 10 minutes.2. Using a diastolic or systolic pressure during 3 minutes, the fibrinolytic activity was about 2.8 times the activity in the control sample.3. Using a pressure halfway the diastolic and systolic, the fibrinolytic activity after 3 minutes was about 3.5 times, and after 10 minutes about 11 times the activity in the control sample.