Blood coagulation studies were carried out in 38 Indian soldiers who were resident at altitudes between I2,000 and i8,0oo feet for 2 years. Compared with I6 sea-level controls, 6 of these 38 subjects who had developed pulmonary hypertension during their stay at high altitude showed a significant increase ofplasmafibrinogen,fibrinolytic activity, platelet adhesiveness, plateletfactor 3, factor V, and factor VIII. In the remaining 32 subjects who did not develop pulmonary hypertension there was a significant increase of plasma fibrinogen and fibrinolytic activity only. The above differences between subjects who develop pulmonary hypertension at high altitude and those who do not develop pulmonary hypertension suggest that high altitude pulmonary hypertension is of occlusive origin and is dependent on changes in blood coagulation at high altitude. Campos and Iglesias (I957) observed an obvious dilatation of the vascular bed of the lungs. There is also thickening of the muscular layer of the small pulmonary arteries and muscularization of the pulmonary arterioles (Arias-Stella and Saldania, I962). Pen'ialoza et al. (I963) attributed high altitude pulmonary hypertension to increased pulmonary vascular resistance resulting from widespread narrowing of the lumen of the pulmonary blood vessels on account of these changes. However, in our experience with soldiers temporarily posted at high altitudes, who develop pulmonary hypertension and die of it, these changes are not prominent (see below). It seems more likely that these changes are not causal but secondary to long-standing hypertension. The pulmonary blood flow, as indicated by a normal cardiac output, is not increased in pulmonary hypertension. In itself, therefore, an increased pulmonary vascular bed is not contributory. In the absence of these changes, dilatation of the vascular bed may be found Received 29 July 197I. in association with an increased pulmonary blood volume, but without pulmonary hypertension.Polycythaemia per se does not seem to predispose to pulmonary hypertension. Pulmonary hypertension may be present without polycythaemia, or it may persist after the red blood cell count has returned to normal when the individual has returned to sea-level.In our soldiers who are temporarily posted from sea-level to altitudes in the Himalayas, the symptoms of pulmonary hypertension begin after a stay of 5 to 42 months at high altitude. After the initial onset of the disease, periodic returns to sea-level on leave for 2 to 3 months once a year do not alter the picture. The hypertension either persists at sea-level or, if it abates, it reappears within 2 to 3 weeks after the individual returns to high altitude. Though pulmonary vasoconstriction, increased pulmonary blood volume, and polycythaemia may have some role in the pathogenesis of high altitude pulmonary hypertension, these bases do not explain its slow disappearance or persistence when the subjects return to sea-level.In a previous study (Singh et al., i965), based on necropsy findings in high altitude...
Yoga,an ancient Indian cult,is knovn to endow one with perfect physical,mental and spiritual health. Its effect on blood coagulation is not known. A pilot study was conducted, Seven adult males underwent a combination of yogic exercises, daily one hour,for 4 months. Parameters of blood coagulation were estimated before commencement of yoga and then repeated at the end of training. These included: haemoglobin(Hb) gm/dl,haematocrit (Hct), blood platelet counts in thousands/cu mm, activated partial thromboplastin time(APTT) sec, platelet aggregation time(FAT) sec, fibrinogen mg/dl, and euglobulin fibrinolytic activityfFA) measured as area of lysis in sq mm. Final results were compared with the initial ones. All values are expressed as Mean ± SEM.Following yoga, Hb Showed a significant rise from 13.5 ±;, 0.1 to 14.5 ± 0.3 and so did Hct from 44.5 ± 1.1 to 49.3 ± 1.2. FA increased significantly from 271 ± 36 to 443 ± 6 4, it was accompanied by a fall in fibrinogen from 2 54± 17 to 202 ± 10. APTT prolonged from 16.4 ± 0.2 to 17.4 ± 0.7 and so did PAT from 3 3 .O ± 3 .? to 40.1 ± 9.75 though differences here were not significant. Blood platelet counts showed a marginal but significant rise from 336.6 ± 26.3 to 391.6 ± 10.0.This study suggests that yoga induces a state of hypocoagulability evident by raised FA,fall in fibrinogen,suppressed platelet activity and low levels of activated clotting factors. Yogic exercises,therefore,may be instituted for prevention of cardiovascular and thrombotic disorders in man. Benefits of yoga seem to accrue from oarasympathodominance and symnathetic quiescence of the autonomic nervous system brought about by yoga.
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