A total of 80 patients with chronic, stable psoriasis, 34 of whom also had psoriatic arthritis, were treated with 1122 mg/day eicosapentaenoic acid ethyl ester and 756 mg/day docosahexaenoic acid ethyl ester. Before the study and after 4 and 8 weeks of treatment a Psoriatic Association scoring index (PASI) score was assessed. Before treatment the mean PASI score was 3.56, after 4 weeks 1.98 and after 8 weeks 1.24; the decrease in the score was highly significant (P less than 0.001). The degree of pruritus decreased most rapidly, followed by scaling and induration of the plaques, and erythema was most persistent. At the end of the trial, seven patients were completely healed and in 13 other patients more than 75% healing was observed but in 14 patients the result was poor. The majority of patients with psoriatic arthritis reported a subjective improvement in joint pain during the study. It is concluded that polyunsaturated ethyl ester lipids may be useful for the treatment of psoriasis and psoriatic arthritis and may provide an important adjuvant to standard therapy of both conditions.
Imedeen, a new compound for oral administration consisting of special protein fractions and some glucosaminoglycans extracted from marine fish, has been shown in previous pilot studies to have a repairing effect on sun-damaged skin. In an open study, 10 females with sun-damaged skin, aged 39-61 years, were treated with 0.5 g/day Imedeen for 90 days. At baseline and after 30, 60 and 90 days, the following parameters were clinically evaluated: wrinkles; mottles; dryness of skin; and brittleness of hair and nails. After 90 days' treatment all signs of sun-damage had improved and brittleness of hair and nails was normalized in all cases. These clinical observations were confirmed by changes in skin thickness and elasticity. In a second double-blind study, 30 females in the same age range and with similar signs of sun-damage were treated with 0.5 g/day Imedeen or placebo for 90 days. The results in the Imedeen-treated group corresponded to those in the first study whereas no response to treatment was observed in the placebo treatment group.
In the present double-blind investigation, the effects of a new formulation of natural cartilage polysaccharides on sundamaged skin were studied in women aged 40-60 years. A group of 15 women were treated orally with 500 mg/day active substance (Vivida) for 90 days and a second group of 15 women received 500 mg/day placebo for 90 days. Clinical examinations after 45 and 90 days' treatment showed significant improvements in skin condition in the actively treated group but not in the placebo group (P less than 0.001). In the Vivida-treated patients, the epidermal thickness increased after 90 days from 0.11 mm to 0.29 mm, dermal thickness from 0.74 mm to 1.39 mm, skin elasticity index from 44% to 73% and the erythemal index decreased from 0.301 to 0.205. No changes were observed in the placebo group and no adverse effects were reported by either treatment group.
Fifty heterosexual male patients with histologically verified genital warts of short duration ( < 3 months) were randomly allocated to treatment with either 0 25% or 05% idoxuridine
Evidence is accumulating that cartilage polysaccharides derived from marine fish have a repairing effect on solar elastosis. In a double-blind trial, the efficacy and safety of two commercial preparations, Vivida and Imedeen, were compared in the treatment of sun-damaged skin in women aged 40-60 years. A group of 15 women received 500 mg/day Vivida and another 15 women received 380 mg/day Imedeen orally for 90 days. Subjective assessment revealed statistically significant improvements in skin condition in both treatment groups but Vivida was significantly (P less than 0.01) more effective than Imedeen for all parameters. In the Vivida group, mean epidermal thickness increased from 0.14 to 0.26 mm, dermal thickness from 0.90 to 1.51 mm and the elasticity index from 47% to 71%. In the Imedeen group, epidermal thickness increased from 0.13 to 0.18 mm, dermal thickness from 0.80 to 0.97 mm and the elasticity index from 48% to 56%. After 90 days, the differences between the two groups for all three parameters were statistically significant (P less than 0.001). The mean erythemal index decreased from 0.24 to 0.20 in the Vidida group, but increased from 0.23 to 0.25 in the Imedeen group. In the Vivida group, five patients developed transient, mild pimples during the first weeks of treatment, but no other adverse effects occurred.
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