Effects of Dietary Supplementation with Polyunsaturated Ethyl Ester Lipids (Angiosan®) in Patients with Psoriasis and Psoriatic Arthritis

Abstract

A total of 80 patients with chronic, stable psoriasis, 34 of whom also had psoriatic arthritis, were treated with 1122 mg/day eicosapentaenoic acid ethyl ester and 756 mg/day docosahexaenoic acid ethyl ester. Before the study and after 4 and 8 weeks of treatment a Psoriatic Association scoring index (PASI) score was assessed. Before treatment the mean PASI score was 3.56, after 4 weeks 1.98 and after 8 weeks 1.24; the decrease in the score was highly significant (P less than 0.001). The degree of pruritus decreased most rapidly, followed by scaling and induration of the plaques, and erythema was most persistent. At the end of the trial, seven patients were completely healed and in 13 other patients more than 75% healing was observed but in 14 patients the result was poor. The majority of patients with psoriatic arthritis reported a subjective improvement in joint pain during the study. It is concluded that polyunsaturated ethyl ester lipids may be useful for the treatment of psoriasis and psoriatic arthritis and may provide an important adjuvant to standard therapy of both conditions.

Clinical evaluation of omega-3 fatty acids in psoriasis

“…They found a significant difference in the response shown by the group of patients treated with tacalcitol ointment along with 640 mg of omega-3 fatty acids compared to another group treated with tacalcitol ointment only [18]. Similar results were observed by Lassus et al in an open trial conducted in patients with chronic plaque psoriasis treated with 1.9 g of omega-3 fatty acids [27]. PASI 50 was achieved by 46.3% of patients in group A and 13.9% of patients in group B.…”

“…PASI 50 was achieved by 46.3% of patients in group A and 13.9% of patients in group B. The authors observed that 16.25% of patients showed a 75% reduction in PASI score after omega-3 fatty acid supplementation, while 84.75% of patients had a moderate improvement in their PASI scores [27]. Mayser et al observed that 37% of patients achieved significant improvement in PASI scores in a double blinded trial evaluating the efficacy of intravenous omega-3 fatty acid infusions [15].…”

“…Dane z literatury światowej wskazują, że łuszczyca [27]. PASI 50 was achieved by 46.3% of patients in group A and 13.9% of patients in group B.…”

“…w otwartym badaniu przeprowadzonym u pacjentów z przewlekłą łuszczycą pospolitą, którzy przyjmowali 1,9 g kwasów omega-3 [27]. PASI 50 uzyskano u 46,3% pacjentów w grupie A i 13,9% pacjentów w grupie B. U 16,25% pacjentów autorzy zaobserwowali obniżenie PASI o 75% wskutek suplementacji kwasami omega-3, a u 84,75% -umiarkowaną poprawę wskaźnika PASI [27]. W badaniu z podwójnie ślepą próbą oceniającym skuteczność kwasów omega-3 w postaci wlewów Mayser i wsp.…”

“…Zdecydowaną poprawę stanu pacjentów w zakresie powierzchni zmian skórnych zaobserwowali Kragballe i Fogh u pacjentów przyjmujących 9 g kwasów omega-3 na dobę przez 4 miesiące, jednak poprawa w zakresie nasilenia rumienia i łuski nie była istotna [30]. W badaniu Lassusa wykazano, że kwasy omega-3 w dawce 1,9 g zmniejszają nasilenie łuski i nacieku, jednak nie powodują zmian w zakresie rumienia [27]. Opublikowano kilka badań, w których potwierdzono poprawę parametrów nasilenia zmian łuszczycowych dzięki stosowaniu kwasów omega-3 w różnych dawkach [31].…”