Background: Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long-term data are scarce. This study aimed to assess the outcome of patients treated with resection for SC.Methods: Patients treated at four tertiary centres were included. Cumulative incidence curves were calculated for recurrences.Results: A total of 100 patients (57 males, 57%) were included with 103 SCs. The median age was 72 (range, 15-95) years with a median follow-up of 52 (interquartile range [IQR], 24-93) months. Most SCs were located (peri)ocular (49.5%). Of all SCs, 17 locally recurred (16.5%) with a median time to recurrence of 19 (IQR, months. The cumulative incidence probability for recurrence was statistically higher for (peri)ocular tumours (p = 0.005), and for positive resection margins (p = 0.001).Two patients presented with lymph node metastases and additional seven patients (8.7%) developed lymph node metastases during follow-up with a median time to metastases of 8 (IQR, 0.5-28) months. Three patients had concurrent in-transit metastases and one patient also developed liver and bone metastases during follow-up.
Conclusion:SC is a rare, yet locally aggressive tumour. Positive resection margins and (peri)ocular SCs are more frequently associated with local recurrence. SC infrequently presents with locoregional or distant metastases.
In 67 cases of pleura mesothelioma and in matched controls (cardiovascular disease) a retrospective in depth interview was carried out In 72 % of cases occupational exposure to asbestos was elucidated, whereas in matched controls only 18 % had a positive exposure history In 60 % of cases with positive history there had been a rather intensive exposure, however often intermittent; duration of exposure often was over 10 yr, latent period over 30 yr In individual cases a short duration of exposure and/or latent period was observed A relationship with smoking history could not be confirmed Some unexpected possibilities for occupational exposure were found All 67 cases were reviewed by a panel of pathologists; in 66 % the diagnosis could be confirmed; in the other cases the diagnosis was never fully rejected It could be shown that histological confirmation of diagnosis is highly dependent on adequate supply of material, at least to be obtained through thoracotomy, pleurectomy, preferably through autopsy The authors stress the methodological aspects of a restrospective study: absolute underreporting dependent on method of history taking, relative underreporting dependent on method of selection of controls Prevalences as reported in literature cannot be taken at their face value because of pitfalls in study design.
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