Nine Years’ Toxicity Control In Insecticide Plants

Hoogendam, I.; Versteeg, J. P. J.; Vlieger, M. de

doi:10.1080/00039896.1965.10664026

Cited by 32 publications

(8 citation statements)

References 4 publications

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“…The EEGs returned to normal wi thin 2 to 6 months ,after -the termination of exposure. Later the sam'e research group published a 9-year follow-up Df the workers in an insecticide plant (26). During this period 17 workers, 5 0/0 of the total labor force, suffered from epileptic convulsions.…”

Section: Insecticidesmentioning

confidence: 99%

Applications of neurophysiological methods in occupational medicine. A review.

Am¹

1975

Scand J Work Environ Health

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Section: Insecticidesmentioning

confidence: 99%

Applications of neurophysiological methods in occupational medicine. A review.

Am¹

1975

Scand J Work Environ Health

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“…Aldrin (9), Dieldrin (10) and Endrin (11), highly chlorinated hydrocarbons used as insecticides, are reproductive [ 4] and nerve toxins [58][59][60]. The mode of action probably involves the initial formation of an epoxide under oxidative conditions followed by nucleophilc attack by -SH groups on the nerve cells.…”

Section: Aldrin Dieldrin and Endrinmentioning

confidence: 99%

Neurotoxicity: The Broad Framework of Electron Transfer, Oxidative Stress and Protection by Antioxidants

Kovacic¹,

Somanathan²

2005

CMCCNSA

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A broad overview of neurotoxins is presented based on electron transfer, reactive oxygen species, and oxidative stress. Although mode of action is complex, these aspects evidently play an important role in many cases. It is relevant that metabolites from toxins generally possess electron transfer functionalities which can participate in redox cycling. Much evidence exists in support of the theoretical framework. Toxic effects at the molecular level include lipid peroxidation, DNA attack, adduction, enzyme inhibition, oxidative attack on the CNS, and cell signaling. The toxins fall into many categories, including drugs, industrial chemicals, abused drugs, reproductive toxins, metal compounds, pesticides, and herbicides. Beneficial effects of antioxidants are documented, which may prove clinically useful. Knowledge of mechanisms operating in CNS insults should prove useful in drug design.

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“…The lack of any abnormality two and 26 days after exposure sets chlordarie apart from dieldrin and endrin where electrical activity may be abnormal for months after exposure,7,S and is characteristic enough to be used for the control of the exposure of industrial workers. 8 Although the convulsions of the acute phase of single-dose chlordane poisoning may not be prolonged, and the patient may appear entirely normal when they cease, further considerations are warranted. First, the highest level in fat may be expected after one week, and this level is the best indicator of the amount originally absorbed.…”

Section: Commentmentioning

confidence: 98%