Long-term occupational exposure to the insecticides aldrin dieldrin, endrin, and telodrin

Versteeg, J. P. J.; Jager, K. W.

doi:10.1136/oem.30.2.201

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…K is the first-order rate constant for elimination of dieldrin from the human body. The biological half-life of dieldrin was calculated to be 267 days (Versteeg and Jager, 1973). Assuming a stable exposure rate, we estimated the total intake of dieldrin and aldrin for each worker, based on the biomonitoring data.…”

Section: Study Populationmentioning

confidence: 99%

Cancer mortality in workers exposed to dieldrin and aldrin: an update

et al. 2002

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This study was conducted to investigate the possible long-term health effects, in particular carcinogenic effects, of occupational exposure to the organochlorine insecticides dieldrin and aldrin. We updated an earlier cohort mortality study of 570 employees involved in the production of these insecticides. All of the employees had worked in the production plants between 1 January 1954 and 1 January 1970 and were followed for cause-specific mortality until 1 January 2001. Based on dieldrin levels in blood samples taken during the exposure period, available for 343 workers, individual estimates of the total intake of dieldrin were estimated for all individual subjects in the cohort. The estimated total intake ranged from 11 to 7755 mg of dieldrin, with an average of 737 mg. One hundred and seventy-one workers had died before 1 January 2001, compared with an expected number of 226.6, giving a standardized mortality ratio (SMR) of 75.6 [95% confidence interval (CI): 64.6-87.7]. This deficit in total mortality was mainly attributable to a deficit in cardiovascular disease mortality, but cancer mortality was also lower than expected. The observed number of deaths from rectal cancer was significantly higher than expected (SMR = 300.0; 95% CI: 109.5-649.3), but was most pronounced in the low-intake subgroup and appears to be unrelated to exposure to dieldrin and aldrin. This study reinforces the earlier findings that occupational exposure of workers to significant amounts of dieldrin and aldrin has not led to a higher cancer mortality than would be found in an unexposed population.

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Section: Study Populationmentioning

confidence: 99%

Cancer mortality in workers exposed to dieldrin and aldrin: an update

et al. 2002

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“…"K" is the Wrst order rate constant for elimination of dieldrin from the human body. The biological half-life of dieldrin was calculated to be 267 days (Versteeg and Jager 1973). Assuming a stable exposure rate the total intake of dieldrin and aldrin for each worker was estimated based on the biomonitoring data.…”

Section: Study Populationmentioning

confidence: 99%

Cancer mortality in workers exposed to dieldrin and aldrin: over 50 years of follow up

Amelsvoort

Slangen

Tsai

et al. 2008

Int Arch Occup Environ Health

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Objective Dieldrin and aldrin, pesticides widely used until the 1970s, have been under suspicion of being carcinogenic. In this study, overall and cause-speciWc mortality was assessed in a cohort of 570 employees occupationally exposed to the pesticides dieldrin and aldrin to investigate the long-term health eVects, in particular carcinogenic eVects. Methods All of the employees worked in the production plants between January 1954 and January 1970 and were followed for cause-speciWc mortality until 30 April 2006. Based on dieldrin levels in blood samples taken from 343 workers during the exposure period, the total intake of dieldrin was estimated for each individual subjects in the cohort. The estimated total intake ranged from 11 to 7,755 mg of dieldrin, with an average of 737 mg. Results Two hundred and twenty-six workers had died before 30 April 2006 compared with an expected number of 327.3, giving a standardized mortality ratio (SMR) of 69.0 (95% conWdence interval (CI): 60.3-78.7). Overall cancer mortality was also signiWcantly lower than expected (SMR: 76.4,). Also, none of the speciWc cancer sites showed a signiWcant excess mortality and no association between exposure level and cancer mortality was found. ConclusionThe results from this study support Wndings from other epidemiological and recent animal studies concluding that dieldrin and aldrin are not likely human carcinogens.

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Mortality study of industrial workers exposed to aldrin, dieldrin and endrin

1985

Int Arch Occup Environ Health

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Vital status and cause of death were assessed for 232 of a group of 233 workers engaged in the manufacturing and formulation of aldrin, dieldrin, endrin and (for a limited period) Telodrin. This group is part of the total exposed population of more than 1000 workers and was selected for follow up on account of the high exposures in the initial years of manufacturing and formulation and of the long exposure (mean 11 years) and observation (mean 24 years) periods. Total observed mortality was 25 versus 38 expected on the basis of the death statistics of the male Dutch population. Of the 9 cancer deaths, 3 were caused by lung cancer, while the remaining 6 were each of a different nature. Although in this group exposures have been high and exposure, as well as observation periods, were long enough for meaningful evaluation, this study revealed no indication of a specific carcinogenic activity of aldrin, dieldrin or endrin in manufacturing plant workers exposed to these products.

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Long-term occupational exposure to the insecticides aldrin dieldrin, endrin, and telodrin

Cited by 6 publications

References 2 publications

Cancer mortality in workers exposed to dieldrin and aldrin: an update

Cancer mortality in workers exposed to dieldrin and aldrin: an update

Cancer mortality in workers exposed to dieldrin and aldrin: over 50 years of follow up

Mortality study of industrial workers exposed to aldrin, dieldrin and endrin

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