Mortality study of industrial workers exposed to aldrin, dieldrin and endrin

Ph, Ribbens

doi:10.1007/bf00379378

Cited by 23 publications

(5 citation statements)

References 6 publications

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“…Our finding that lung cancer relative risk increased significantly with increasing dieldrin exposure was previously reported in an earlier AHS analysis by Alavanja et al9 Dieldrin produces liver tumors in mice, though not in other animal models,13 and has been reported to induce chromosomal damage in a dose‐response manner in a human embryonic lung cell line 35. However, no elevated cancer rates were observed among workers employed in the manufacture of dieldrin, aldrin and endrin 36, 37, 38…”

Section: Discussionsupporting

confidence: 79%

Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study

Purdue

Hoppin

Blair

et al. 2006

Intl Journal of Cancer

178

122

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Organochlorine (OC) insecticides have been regulated as possible human carcinogens primarily on the basis of animal studies. However, the epidemiologic evidence is inconsistent. We investigated the relationship between cancer incidence and OC insecticide use among pesticide applicators enrolled in the Agricultural Health Study, a prospective cohort study of 57,311 licensed applicators in Iowa and North Carolina enrolled between 1993 and 1997. Information on ever use of 7 OC insecticides (aldrin, chlordane, DDT, dieldrin, heptachlor, lindane, toxaphene) was collected from a selfadministered questionnaire at enrollment. Lifetime exposure-days to OC insecticides were calculated using additional data from a take-home questionnaire completed by 25,291 participants (44% of total). We found no clear evidence of an association between use of OC insecticides and incident cancers (N 5 1,150) ascertained through December, 2002. When we focused on individual insecticides and structurally similar groups (aldrin and dieldrin; chlordane and heptachlor), significantly increased relative risks of some cancers were observed for use of some chemicals (rectal cancer and chlordane, lung cancer and dieldrin, non-Hodgkin lymphoma (NHL) and lindane, melanoma and toxaphene, leukemia and chlordane/heptachlor). Some significant decreased relative risks were also observed (colon cancer and aldrin; overall cancer and heptachlor). In conclusion, we did not observe any clear relationship between cancer risk and the use of OC insecticides. Our chemicalspecific findings are based on small numbers and multiple comparisons, and should be interpreted with caution; however, some observed associations (lindane and NHL, chlordane/heptachlor and leukemia) are supported by previous evidence. ' 2006 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 79%

Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study

Purdue

Hoppin

Blair

et al. 2006

Intl Journal of Cancer

178

122

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“…Although cancer mortality has been studied in several occupational groups exposed to aldrin and dieldrin, cohorts were small and the studies lacked sufficient statistical power to observe any but the strongest carcinogenic effects for relatively rare cancers such as NHL (30)(31)(32)(33)(34). Two small case-control studies of leukemia and lymphoma examined levels of aldrin/dieldrin in the bone marrow at diagnosis, with no observed differences (35,36).…”

Section: Discussionmentioning

confidence: 99%

Risk of non-Hodgkin's lymphoma and prediagnostic serum organochlorines: beta-hexachlorocyclohexane, chlordane/heptachlor-related compounds, dieldrin, and hexachlorobenzene.

Cantor

Strickland

Brock

et al. 2003

Environ Health Perspect

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Increases in non-Hodgkin's lymphoma (NHL) incidence and mortality rates during the past few decades remain largely unexplained. Studies suggest that organochlorine pesticides may contribute to an increased risk of NHL. In 1974, serum samples were obtained from 25,802 participants in the Campaign Against Cancer and Stroke in Washington County, Maryland (USA), and cryopreserved for future study. We measured prediagnostic levels of chlordane, lindane (gamma-hexachlorocyclohexane), beta-hexachlorocyclohexane, transnonachlor, heptachlor, heptachlor epoxide, oxychlordane, dieldrin, and hexachlorobenzene in serum samples of 74 cases of NHL and 147 matched controls. Previously, we found an association between NHL and serum levels of total PCBs (polychlorinated biphenyls), but not DDT (dichlorodiphenyltrichloroethane) and related compounds. In this instance, there was no evidence of an association between NHL risk and serum levels of any of the individual lipid- and recovery-corrected organochlorines that we evaluated, nor of the summed chlordane-related compounds (transnonachlor, heptachlor, heptachlor epoxide, oxychlordane). These findings do not support the hypothesis that the organochlorine compounds included in this study are strongly linked to the development of NHL. The possibility of a weak association cannot be excluded by these data.

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“…A recent study of outdoor workers in Australia showed a fivefold increased risk associated with DDT application (20). Six other studies of workers who manufactured pesticides, however, did not find a pancreatic cancer excess (11,64,118,242,253,304), nor did four studies among farmers or farmworkers (35,44,115,250).…”

Section: Pancreatic Cancermentioning

confidence: 91%

Health Effects of Chronic Pesticide Exposure: Cancer and Neurotoxicity

Alavanja

Hoppin

Kamel

2004

Annu. Rev. Public Health

639

369

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health s Abstract Pesticides are widely used in agricultural and other settings, resulting in continuing human exposure. Epidemiologic studies indicate that, despite premarket animal testing, current exposures are associated with risks to human health. In this review, we describe the routes of pesticide exposures occurring today, and summarize and evaluate the epidemiologic studies of pesticide-related carcinogenicity and neurotoxicity in adults. Better understanding of the patterns of exposure, the underlying variability within the human population, and the links between the animal toxicology data and human health effects will improve the evaluation of the risks to human health posed by pesticides. Improving epidemiology studies and integrating this information with toxicology data will allow the human health risks of pesticide exposure to be more accurately judged by public health policy makers.

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Mortality study of industrial workers exposed to aldrin, dieldrin and endrin

Cited by 23 publications

References 6 publications

Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study

Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study

Risk of non-Hodgkin's lymphoma and prediagnostic serum organochlorines: beta-hexachlorocyclohexane, chlordane/heptachlor-related compounds, dieldrin, and hexachlorobenzene.

Health Effects of Chronic Pesticide Exposure: Cancer and Neurotoxicity

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