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By comparison to the cellular constituents of the retinas of certain other diving mammals, the elements of the dolphin retina include an unusually large number of specialized cells. Both cone and rod receptors may be identified. An unusual amacrine cell may be seen which produces a process that spans the cells between the inner plexiform and outer plexiform layers. Most unusual is a layer of giant ganglion cells which appears to serve most of the central retina. The giant ganglion cells support giant dendrites and optic nerve fibers which range up to 8 micrometers in diameter.

We have implemented and evaluated a positron emission tomography (PET) demonstrator using two monolithic detector blocks operating in coincidence with dedicated applicationspecific integrated circuit (ASIC) readout. Each detector is composed of a monolithic lutetium yttrium orthosilicate (LYSO) scintillator coupled to a pair of Hamamatsu S8550-02 APD arrays. The front-end electronics of this demonstrator is based on the VATA240 ASIC readout, which sums the charge provided by each row and column of the APD array. The ASIC has been characterized obtaining a noise per row or column less than 2000 electrons rms with the APD at its inputs and a good linear response in the range from 5 fC to 30 fC. We have acquired energy spectra of 22 Na and 137 Cs radioactive sources, achieving energy resolutions between 13.2% and 14.1% full width at half maximum (FWHM) at 511 keV. We have estimated the interaction position over the surface of the monolithic blocks using Neural Networks (NN) position determining algorithms, obtaining spatial resolutions at the detector level down to 2.1 mm FWHM. By using this detector technology and electronics we have achieved images of point sources with spatial resolutions as good as 2.1 mm FWHM for filtered back projection (FBP) reconstructions methods with single slice rebinning (SSRB). Based on the results obtained with this demonstrator, we are developing a PET insert for existing magnetic resonance imaging (MRI) equipment, to be installed in a collaborating hospital and used for clinical PET-MRI of the human brain.Index Terms-Application specific integrated circuit, artificial neural networks, position sensitive detectors, positron emission tomography.

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We are presently developing a novel PET scanner for human brain functional imaging based on monolithic scintillator crystals read by APD matrices, capable of being inserted into an MRI system. In this work we report on the detailed study that has been made of the design of the detector blocks, aiming at defining the most suitable geometrical and readout configuration for optimizing the overall performance of the entire scanner. Both parallel and trapezoidal geometries have been simulated, featuring two layers of active scintillator material with different or similar thickness and APD readout on the front or back side. Results of this study indicate that a trapezoidal geometry with equal thickness of both layers is the best solution for improving the expected scanner performance.