NEMA NU 4-2008 Performance Measurements of Two Commercial Small-Animal PET Scanners: ClearPET and rPET-1

Canadas, M.; Embid, M.; Lage, Eduardo; Desco, Manuel; Vaquero, J.J.; Pérez, J. M.

doi:10.1109/tns.2010.2072935

Cited by 32 publications

(32 citation statements)

References 21 publications

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“…Since the 1990s, significant efforts in the development of small animal PET prototype scanners have pushed the limits of resolution and sensitivity with various approaches (Bloomfield et al, 1995; Lecomte et al, 1996; Cherry et al, 1997; Chatziioannou et al, 1999; Jeavons et al, 1999; Weber et al, 2000; Di Domenico et al, 2003; Seidel et al, 2003; Surti et al, 2003; Tai et al, 2003; Correia et al, 2004; Rouze et al, 2004; Miyaoka et al, 2005; Schafers et al, 2005; Ziemons et al, 2005; Li et al, 2007; Bergeron et al, 2009; Lage et al, 2009; Prasad et al, 2010; Zhang et al, 2011; Szanda et al, 2011; Canadas et al, 2011; Sanchez et al, 2012). Commercial preclinical PET systems also became available since 2000 (Tai et al, 2001; Knoess et al, 2003; Tai et al, 2005; Laforest et al, 2007; Schafers et al, 2005; Wang et al, 2006; Huisman et al, 2007; de Jong et al, 2007; Bao et al, 2009; Canadas et al, 2011; Prasad et al, 2010, 2011; Szanda et al, 2011). The performance and capabilities of these systems evolved rapidly and have led to an increased use and acceptance of in vivo molecular imaging techniques in biological laboratories.…”

Section: Introductionmentioning

confidence: 99%

NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph

Taschereau

et al. 2013

Phys. Med. Biol.

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PETbox4 is a new, fully tomographic bench top PET scanner dedicated to high sensitivity and high resolution imaging of mice. This manuscript characterizes the performance of the prototype system using the National Electrical Manufacturers Association (NEMA) NU 4–2008 standards, including studies of sensitivity, spatial resolution, energy resolution, scatter fraction, count-rate performance and image quality. The PETbox4 performance is also compared with the performance of PETbox, a previous generation limited angle tomography system. PETbox4 consists of four opposing flat-panel type detectors arranged in a box like geometry. Each panel is made by a 24 × 50 pixelated array of 1.82 × 1.82 × 7mm bismuth germanate (BGO) scintillation crystals with a crystal pitch of 1.90mm. Each of these scintillation arrays is coupled to two Hamamatsu H8500 photomultiplier tubes via a glass light guide. Volumetric images for a 45 × 45 × 95 mm field of view (FOV) are reconstructed with a maximum likelihood expectation maximization (ML-EM) algorithm incorporating a system model based on a parameterized detector response. With an energy window of 150–650 keV, the peak absolute sensitivity is approximately 18% at the center of FOV. The measured crystal energy resolution ranges from 13.5% to 48.3% full width at half maximum (FWHM), with a mean of 18.0%. The intrinsic detector spatial resolution is 1.5mm FWHM in both transverse and axial directions. The reconstructed image spatial resolution for different locations in the FOV ranges from 1.32mm to 1.93 mm, with an average of 1.46 mm. The peak noise equivalent count rate for the mouse-sized phantom is 35 kcps for a total activity of 1.5 MBq (40 µCi) and the scatter fraction is 28%. The standard deviation in the uniform region of the image quality phantom is 5.7%. The recovery coefficients range from 0.10 to 0.93. In comparison to the first generation two panel PETbox system, PETbox4 achieves substantial improvements on sensitivity and spatial resolution. The overall performance demonstrates that the PETbox4 scanner is suitable for producing high quality images for molecular imaging based biomedical research.

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Section: Introductionmentioning

confidence: 99%

NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph

Taschereau

et al. 2013

Phys. Med. Biol.

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“…Phantom and line source were placed at the center of the scanner, separately. Then, measurements were performed for different energy windows [26,27].…”

Section: Scatter Fractionmentioning

confidence: 99%

Design and performance evaluation of a high resolution IRI-microPET preclinical scanner

rad

Peyvandi²,

Lehdarboni³

et al. 2015

Nuclear Instruments and Methods in Physics Research Section A:

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“…Table 1 summarises the latest relative spatial resolution of human and animal cameras (Bockisch, A. et al, 2009;Cai, W.B. &Chen, X.Y., 2008;Cañadas, M.E. et al, 2008;Kitajima, K. et al, 2011;Lewellen, T.K., 2008;Wang, C. et al, 2010).…”

Section: Pet Imagingmentioning

confidence: 99%

Production and Selection of Metal PET Radioisotopes for Molecular Imaging

Smith¹,

Jones²,

Holmes³

2011

Radioisotopes - Applications in Bio-Medical Science

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NEMA NU 4-2008 Performance Measurements of Two Commercial Small-Animal PET Scanners: ClearPET and rPET-1

Cited by 32 publications

References 21 publications

NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph

NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph

Design and performance evaluation of a high resolution IRI-microPET preclinical scanner

Production and Selection of Metal PET Radioisotopes for Molecular Imaging

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