Simunek J., Eva Hegerova, Jaroslava Klimeliova and Radka Zavadilova: Effect of Sulphadimidine on the Toxicity of Phenobarbital in Cockerels of Different Ages. Acta vet. Brno, 54,1985 : 183-187. Acute toxicity (LD50) of phenobarbital sodium salt administered intramuscularly alone and after premedication with sulphadimidine sodium salt (in i. m. doses of 0.2 gjkg body mass) given 15 or 120 minutes before phenobarbital administration was determined in cockerels aged 7,28 and 49 days.The acute toxicity of phenobarbital decreased with increasing age of the birds. Sulphadimidine premedication did not affect the acute phenobarbital toxicity in 7-day-old cockerels and increased it in 28-and 59-day-old birds, compared to their non-premedicated counterparts, particularly when given 15 minutes before phenobarbital administration. In 28-day-old cockerels this rise in toxicity was significant.Observations for signs of depression within 24 hours of phenobarbital administration showed differences between the birds of the three different ages. The signs were most intense in the oldest birds and particularly in those premedicated with sulphadimidine 15 minutes before phenobarbital administration.Gallus domesticus, LD50 of phenobarbital, sulphadimidine premedication, age-dependence.
Simunek J., E. Hegerova, R. Zavadilova and J. Klimesova The tranquilizing efficacy of diazepam was shown to be dose-dependent and it decreased with ageing of the birds as demonstrated in the experiment on 2-, 5-and 8-week old cockerels given 10 and 30 mg/kg live body mass into the crop. In the second experiment on 2-, 9-and 42-day old birds treated with 15, 50 and 300 mg/kg dependence of diazepam efficacy on its dose and age of the birds was demonstrated, too.The results yielded unequivocal evidence of different sensitivity of cockerels of various ages to the tranquilizing effect of diazepam. They further indicate the possible use of clinical parameters expressed as quantitative indicators for graphic presentation when evaluating efficacy of ataractics.
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