Effect of Sulphadimidine on the Toxicity of Phenobarbital in Cockerels of Different Ages

Abstract

Simunek J., Eva Hegerova, Jaroslava Klimeliova and Radka Zavadilova: Effect of Sulphadimidine on the Toxicity of Phenobarbital in Cockerels of Different Ages. Acta vet. Brno, 54,1985 : 183-187. Acute toxicity (LD50) of phenobarbital sodium salt administered intramuscularly alone and after premedication with sulphadimidine sodium salt (in i. m. doses of 0.2 gjkg body mass) given 15 or 120 minutes before phenobarbital administration was determined in cockerels aged 7,28 and 49 days.The acute toxicity of phenobarbital decreased with increasing age of the birds. Sulphadimidine premedication did not affect the acute phenobarbital toxicity in 7-day-old cockerels and increased it in 28-and 59-day-old birds, compared to their non-premedicated counterparts, particularly when given 15 minutes before phenobarbital administration. In 28-day-old cockerels this rise in toxicity was significant.Observations for signs of depression within 24 hours of phenobarbital administration showed differences between the birds of the three different ages. The signs were most intense in the oldest birds and particularly in those premedicated with sulphadimidine 15 minutes before phenobarbital administration.Gallus domesticus, LD50 of phenobarbital, sulphadimidine premedication, age-dependence.

Effects of Sulphadimidine on the Toxicity of Phenobarbital, Pentetrazole and Bemegride in Mice of Different Ages

“…A previous study from our laboratory (Simunek et al 1985) was concerned with the effects of sulphadimidine premedication on the acute toxicity of phenobarbital in cockerels of different ages. The impetus to the study was possible simultaneous action of the two pharmaceuticals in flocks where SedophenR, a drug containing phenobarbital, is used to tranquilize chickens and sulphadimidine is used therapeutically, e. g. to combat coccidiosis.…”