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The polar parts of the title plant gave several lignans including six new ones named vladinol A-F. The structures were elucidated by high field (1)H-NMR spectroscopy and a few chemical reactions. The stereochemistry was determined by the observed NOE's and by comparison of the (1)H-NMR data with those of related lignans.

The polar fractions of the extract of the aerial parts of CALENDULA PERSICA afforded eight sesquiterpene glycosides, five derived from viridiflorol, two of beta-eudesmol, and one of 4alpha-hydroxygermacra-1(10) E,5E-diene. In addition to fucopyranosides, also chinovopyranosides were present. The structures were elucidated by high field NMR techniques.

Isolation from Calea prunifolia of sesquiterpenes derived from acorane, daucane, and a new type of alicyclic sesquiterpene carbon skeleton, caleprunane, is described. Furthermore, two benzofurans were isolated. The structures were elucidated by spectroscopic methods.From the large genus Calea (Compositae, tribe Heliantheae, subtribe Neurolaeninae) several species have already been investigated chemically. Most species contain highly oxygenated sesquiterpene lactones (1). Having studied the constituents of a species from Costa Rica, Calea prunifolia H.B.K., we now report the results in this paper.The aerial parts afforded a complex mixture of hydrocarbons that could be separated by AgNOj-coated silica columns and plates. In addition to a-and ß-farnesene, germacrene D, caryophyllene, and dauca-2,11-diene (2), three other hydrocarbons, the 2 8 15

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