No abstract

Thrombelastographic methods have been recently introduced to detect iron mediated hypercoagulability in settings such as sickle cell disease, hemodialysis, mechanical circulatory support, and neuroinflammation. However, these inflammatory situations may have heme oxygenase-derived, coexistent carbon monoxide present, which also enhances coagulation as assessed by the same thrombelastographic variables that are affected by iron. This brief report presents a novel, Sonoclot-based method to detect iron enhanced coagulation that is independent of carbon monoxide influence. Future investigation will be required to assess the sensitivity of this new method to detect iron mediated hypercoagulability in clinical settings compared to results obtained with thrombelastographic techniques.

SummaryThe results of twenty-four ascitic reinfusions in twenty patients, using the Rhodiascit procedure, are reported. The procedure was of no value in the management of patients with spontaneous functional renal failure, but was of considerable value in accelerating hospital discharge of patients with tense ascites but good renal function. Complications of the procedure were few, but tests of blood coagulation became abnormal, the most likely cause of which was deposition of fibrin on to the filtration membrane.

No abstract

The performance of two whole-body monitors in estimating the absorption of an oral dose of cyanocobalamin labelled with WO and WO was compared directly.Measurements were made on the same subjects using both monitors: (a) on the day of administration, when the variation in the counting rate was similar for the monitors: and (b) seven days later when the percentage absorption was estimated. Good agree. ment was obtained. Factors influencing the accuracy of the measurements are compared and discussed.