The IgG and IgM anti-A and anti-B activities from several immune and non-immune O, A and B sera were tested against a panel of weak (A (A3, AX, AND Aend) and weak B (B3 and Bx) red cells. In all cases it is the IgM which agglutinated optimally Ax (or Bx) cells, while IgG and IgM anti-A (or anti-B) reacted similarly with A3 and Aend (or B3) cells. The agglutinating activity of all these ABO antibodies was found straightly related to their association constant for the A (or the B) receptor.
The IgG and IgM anti-A and anti-B activities from several immune and non-immune
O, A and B sera were tested against a panel of weak A(A(3), A(x), and A(end)) and weak B
(B(3) and B(x)) red cells. In all cases it is the IgM which agglutinated optimally A(x) (or Bx) cells,
while IgG and IgM anti-A (or anti-B) reacted similarly with A(3) and A(end) (or B(3)) cells. The
agglutinating activity of all these ABO antibodies was found straightly related to their association
constant for the A (or the B) receptor.
Abstract. The agglutinability of red blood cells of A1, A2, A3, Ax and cis‐AB phenotypes by several anti‐A1 reagents was quantitatively evaluated and found to correlate with the number of A antigenic sites/cell determined by using 125I‐labelled IgG anti‐A. Moreover, anti‐A1 sera could be absorbed by some A2 red blood cells and were inhibited by concentrated saliva from A2 secretor individuals. The significance of these findings is discussed in the light of recent data from the literature.
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