Introduction: Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. It has been reported that the leaves and oil of Neem seeds present antihyperglycemic/hypoglycemic activity. Plathymenia reticulata benth, known as “vinhático”, is a Brazilian cerrado tree that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Objective: To verify weight gain correlating with feed intake in rats with type 1 and non-diabetic diabetes mellitus, undertreatment with Neem and Plathymenia and the association between them. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NDC), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) – positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. The data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, Pearson correlation with a significance level of 5% through the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was lower weight gain in diabetic rats undergoing neem treatment, compared with positive and negative control (-13.00 ± 5.13 vs 150.40 ± 6.80, vs 15.79 ± 7.25, p<0.001); the average daily feed intake was higher in rats treated with neem, compared with positive and negative control (42.00 ± 0.00 vs 26.00 ± 1.26 vs 33.83 ± 0.00; p=0,001). There was no significant difference between the other diabetic groups, except for positive control – insulin. There was also lower weight gain in control animals with Neem, compared with negative control (53.50 ± 4.21 vs 80.00 ± 5.76, p=0.010). The average daily food intake was higher in control animals with Neem compared to negative control (24.00 ± 0.00 vs 15.00 ± 0.00, p=0.029). There was a significant negative correlation between weight gain and food intake in the animals studied (p=0.005). Conclusion: The results allow evaluating a lower weight gain, with higher average daily food intake, in rats treated with Neem, both diabetic and control. This effect may indicate possible use of plant extract in prediabetics, obese diabetics and in the treatment of obesity.
Introduction: The Plathymenia reticulata benth is a herbal medicine that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. Goal: To verify the effect of glycated hemoglobin levels in rats with type 1 and non-diabetic diabetes mellitus, in treatment with Plathymenia Reticulata Benth, Neem and the association between them. compared to insulin. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NdM), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) - positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. Data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, with a significance level of 5% using the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was a significant difference in glycated hemoglobin levels in rats submitted to insulin treatment (6.18 ± 0.36) compared to those submitted to treatment with Neem (10.12 ± 1.29, p=0.047), Plathymenia+Neem (12.09 ± 0.38, p=0.006) and water (10.86 ± 1.26, p=0.015). However, no significant difference was observed between the reduction in glycated hemoglobin levels in the groups submitted to insulin treatment compared to the group treated with Plathymenia (7.30 ± 0.68, p=0.911). Conclusion: The results allow us to evaluate a non-inferiority condition in relation to the use of the Plathymenia when compared to treatment with insulin therapy, positive control in the treatment of type 1 diabetes mellitus. The Plathymeniamay present as a herbal option in the treatment of the disease and prevention of complications. Further studies are necessary to evaluate the effect of the extract on other aspects related to the pathology.
Trata-se de um estudo de caso, descritivo e transversal realizado no período de fevereiro a dezembro de 2019 em uma cidade do Triângulo Mineiro, com objetivo avaliar o benefício dos atendimentos de Equoterapia na motricidade de idosas. Utilizou-se 10 sessões de equoterapia e aplicou-se (no pré e no pós) a avaliação pela Escala Motora para Terceira Idade e a Aptidão Motora Global. Participaram cinco idosas saudáveis. Na pré-avaliação, todas as idosas obtiveram pontuações maiores na orientação espacial e pontuações no equilíbrio menores. Três obtiveram pontuações menores também na motricidade global. Posterior à equoterapia, as cinco idosas permaneceram com pontuações menores no equilíbrio e pontuações maiores na orientação espacial, motricidade fina e esquema corporal. Houve melhora em três pacientes na motricidade global, equilíbrio e esquema corporal. A Equoterapia pareceu contribuir na promoção de benefícios nos aspectos da motricidade em idosas, considerando que não houve piora na aptidão motora geral, propiciando a manutenção ou melhora do desempenho motor.
Introduction: Green tea is associated with a series of health benefits, as is physical training. However, in combination they present little known chronotropic and autonomic cardiac effects. Objective: To evaluate the effect of the association of chronic administration of green tea and physical training on basal heart rate (HR) and heart rate variability (HRV) in Wistar rats. Methods: Forty-three Wistar rats (Rattus norvegicus, var. albinus), paired by weight and age, were distributed among four experimental groups, titled sedentary control (CONsed, n = 10), trained control (CONtre, n = 08), sedentary tea (CHÁsed, n = 16) and trained tea (CHÁtre, n = 09). Ingestion of the tea was ad libitum. The physical training protocol lasted for eight weeks and consisted of sessions of swimming with incremental loads. At the end of the training, basal heart rate and heart rate variability (HRV) in both time and frequency domains were determined. The level of significance adopted was 5% (p < 0.05). Results: Both physical training and consumption of green tea caused higher resting bradycardia than that of the CONsed group animals. Regarding HRV, the CONtre, CHÁsed, and CHÁtre groups presented significantly higher values than the CONsed group. Supplementation with green tea caused an increase in the variance, high frequency (HF) component, and sympathovagal balance as compared to the CONsed group. Physical training (PT) did not enhance any of the parameters evaluated. Conclusions: There was no significant optimization of the hemodynamic or autonomic cardiovascular parameters resulting from the association between the administration of green tea and physical training in Wistar rats. Level of Evidence IV; Case Series.
Objective: To evaluate the functional balance of children with sensory impairments submitted to hippotherapy. Methods: 24 children of both genres equally participated in three groups: cerebral palsy (CP), Down syndrome (DS), and intellectual disability (ID) with the respective age groups (10.71 ± 2.69 years), (12.83 ± 2.64 years), and (11 ± 1.69 years).There were 15 attendances in hippotherapy with riding materials specific to each group. The Pediatric Balance Scale (EEP) was used before the 1st and after the 15th hippotherapy session (pre and post moments) to assess functional balance. The data were analyzed using the Shapiro-Wilk tests (normality), Bartlett test (homogeneity), and, between the pre- and post-care times, the paired t-test (intra-groups) and ANOVA with Bonferroni's multiple comparison tests (between groups), with statistical significance for p < 0.05. Results: in the post-attendance, there was an increase in the EEP score for the three groups (intra groups) with significance for children with ID (p = 0.003) and DS (p = 0.033); the CP group had a lower score (inter groups) in both times, pre (p = 0.003) and post (p = 0.002) attendance. Conclusion: hippotherapy contributed to the functional balance of children with distinct sensory impairments, according to the clinical diagnosis and riding material specific to the group, thus being able to be considered a therapeutic method with relevant benefits regarding the sensory aspects of the population.
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