Introduction: Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. It has been reported that the leaves and oil of Neem seeds present antihyperglycemic/hypoglycemic activity. Plathymenia reticulata benth, known as “vinhático”, is a Brazilian cerrado tree that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Objective: To verify weight gain correlating with feed intake in rats with type 1 and non-diabetic diabetes mellitus, undertreatment with Neem and Plathymenia and the association between them. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NDC), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) – positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. The data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, Pearson correlation with a significance level of 5% through the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was lower weight gain in diabetic rats undergoing neem treatment, compared with positive and negative control (-13.00 ± 5.13 vs 150.40 ± 6.80, vs 15.79 ± 7.25, p<0.001); the average daily feed intake was higher in rats treated with neem, compared with positive and negative control (42.00 ± 0.00 vs 26.00 ± 1.26 vs 33.83 ± 0.00; p=0,001). There was no significant difference between the other diabetic groups, except for positive control – insulin. There was also lower weight gain in control animals with Neem, compared with negative control (53.50 ± 4.21 vs 80.00 ± 5.76, p=0.010). The average daily food intake was higher in control animals with Neem compared to negative control (24.00 ± 0.00 vs 15.00 ± 0.00, p=0.029). There was a significant negative correlation between weight gain and food intake in the animals studied (p=0.005). Conclusion: The results allow evaluating a lower weight gain, with higher average daily food intake, in rats treated with Neem, both diabetic and control. This effect may indicate possible use of plant extract in prediabetics, obese diabetics and in the treatment of obesity.
Introduction: The Plathymenia reticulata benth is a herbal medicine that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. Goal: To verify the effect of glycated hemoglobin levels in rats with type 1 and non-diabetic diabetes mellitus, in treatment with Plathymenia Reticulata Benth, Neem and the association between them. compared to insulin. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NdM), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) - positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. Data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, with a significance level of 5% using the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was a significant difference in glycated hemoglobin levels in rats submitted to insulin treatment (6.18 ± 0.36) compared to those submitted to treatment with Neem (10.12 ± 1.29, p=0.047), Plathymenia+Neem (12.09 ± 0.38, p=0.006) and water (10.86 ± 1.26, p=0.015). However, no significant difference was observed between the reduction in glycated hemoglobin levels in the groups submitted to insulin treatment compared to the group treated with Plathymenia (7.30 ± 0.68, p=0.911). Conclusion: The results allow us to evaluate a non-inferiority condition in relation to the use of the Plathymenia when compared to treatment with insulin therapy, positive control in the treatment of type 1 diabetes mellitus. The Plathymeniamay present as a herbal option in the treatment of the disease and prevention of complications. Further studies are necessary to evaluate the effect of the extract on other aspects related to the pathology.
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